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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

Author

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  • Xianyi Meng

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Bettina Grötsch

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Yubin Luo

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Karl Xaver Knaup

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Michael Sean Wiesener

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Xiao-Xiang Chen

    (Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Jonathan Jantsch

    (University of Regensburg)

  • Simon Fillatreau

    (Université Paris Descartes)

  • Georg Schett

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

  • Aline Bozec

    (Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen)

Abstract

Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in B lymphocytes are poorly defined. Here, we show that hypoxia-inducible factor-1α (HIF-1α) contributes to IL-10 production by B cells. HIF-1α regulates IL-10 expression, and HIF-1α-dependent glycolysis facilitates CD1dhiCD5+ B cells expansion. Mice with B cell-specific deletion of Hif1a have reduced number of IL-10-producing B cells, which result in exacerbated collagen-induced arthritis and experimental autoimmune encephalomyelitis. Wild-type CD1dhiCD5+ B cells, but not Hif1a-deficient CD1dhiCD5+ B cells, protect recipient mice from autoimmune disease, while the protective function of Hif1a-deficient CD1dhiCD5+ B cells is restored when their defective IL-10 expression is genetically corrected. Taken together, this study demonstrates the key function of the hypoxia-associated transcription factor HIF-1α in driving IL-10 expression in CD1dhiCD5+ B cells, and in controlling their protective activity in autoimmune disease.

Suggested Citation

  • Xianyi Meng & Bettina Grötsch & Yubin Luo & Karl Xaver Knaup & Michael Sean Wiesener & Xiao-Xiang Chen & Jonathan Jantsch & Simon Fillatreau & Georg Schett & Aline Bozec, 2018. "Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02683-x
    DOI: 10.1038/s41467-017-02683-x
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    Cited by:

    1. Shuiling Chen & Yang Luo & Yang He & Ming Li & Yongjian Liu & Xishen Zhou & Jianwen Hou & Shaobing Zhou, 2024. "In-situ-sprayed therapeutic hydrogel for oxygen-actuated Janus regulation of postsurgical tumor recurrence/metastasis and wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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