IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-45072-x.html
   My bibliography  Save this article

In-situ-sprayed therapeutic hydrogel for oxygen-actuated Janus regulation of postsurgical tumor recurrence/metastasis and wound healing

Author

Listed:
  • Shuiling Chen

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Yang Luo

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Yang He

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Ming Li

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Yongjian Liu

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Xishen Zhou

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Jianwen Hou

    (Southwest Jiaotong University
    Southwest Jiaotong University)

  • Shaobing Zhou

    (Southwest Jiaotong University
    Southwest Jiaotong University)

Abstract

Surgery is the mainstay of treatment modality for malignant melanoma. However, the deteriorative hypoxic microenvironment after surgery is recognized as a stemming cause for tumor recurrence/metastasis and delayed wound healing. Here we design and construct a sprayable therapeutic hydrogel (HIL@Z/P/H) encapsulating tumor-targeted nanodrug and photosynthetic cyanobacteria (PCC 7942) to prevent tumor recurrence/metastasis while promote wound healing. In a postsurgical B16F10 melanoma model in female mice, the nanodrug can disrupt cellular redox homeostasis via the photodynamic therapy-induced cascade reactions within tumor cells. Besides, the photosynthetically generated O2 by PCC 7942 can not only potentiate the oxidative stress-triggered cell death to prevent local recurrence of residual tumor cells, but also block the signaling pathway of hypoxia-inducible factor 1α to inhibit their distant metastasis. Furthermore, the long-lasting O2 supply and PCC 7942-secreted extracellular vesicles can jointly promote angiogenesis and accelerate the wound healing process. Taken together, the developed HIL@Z/P/H capable of preventing tumor recurrence/metastasis while promoting wound healing shows great application potential for postsurgical cancer therapy.

Suggested Citation

  • Shuiling Chen & Yang Luo & Yang He & Ming Li & Yongjian Liu & Xishen Zhou & Jianwen Hou & Shaobing Zhou, 2024. "In-situ-sprayed therapeutic hydrogel for oxygen-actuated Janus regulation of postsurgical tumor recurrence/metastasis and wound healing," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45072-x
    DOI: 10.1038/s41467-024-45072-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-45072-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-45072-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xianyi Meng & Bettina Grötsch & Yubin Luo & Karl Xaver Knaup & Michael Sean Wiesener & Xiao-Xiang Chen & Jonathan Jantsch & Simon Fillatreau & Georg Schett & Aline Bozec, 2018. "Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    2. Yuanhuan Yu & Xin Wu & Meiyan Wang & Wenjing Liu & Li Zhang & Ying Zhang & Zhilin Hu & Xuantong Zhou & Wenzheng Jiang & Qiang Zou & Fengfeng Cai & Haifeng Ye, 2022. "Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Xin Guan & Liping Sun & Yuting Shen & Fengshan Jin & Xiaowan Bo & Chunyan Zhu & Xiaoxia Han & Xiaolong Li & Yu Chen & Huixiong Xu & Wenwen Yue, 2022. "Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45072-x. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.