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Neurons along the auditory pathway exhibit a hierarchical organization of prediction error

Author

Listed:
  • Gloria G. Parras

    (Institute of Neuroscience of Castilla y León (INCYL)
    The Salamanca Institute for Biomedical Research (IBSAL))

  • Javier Nieto-Diego

    (Institute of Neuroscience of Castilla y León (INCYL)
    The Salamanca Institute for Biomedical Research (IBSAL))

  • Guillermo V. Carbajal

    (Institute of Neuroscience of Castilla y León (INCYL)
    The Salamanca Institute for Biomedical Research (IBSAL))

  • Catalina Valdés-Baizabal

    (Institute of Neuroscience of Castilla y León (INCYL)
    The Salamanca Institute for Biomedical Research (IBSAL))

  • Carles Escera

    (Department of Clinical Psychology and Psychobiology, University of Barcelona
    University of Barcelona
    Institut de Recerca Sant Joan de Déu)

  • Manuel S. Malmierca

    (Institute of Neuroscience of Castilla y León (INCYL)
    The Salamanca Institute for Biomedical Research (IBSAL)
    Faculty of Medicine, University of Salamanca)

Abstract

Perception is characterized by a reciprocal exchange of predictions and prediction error signals between neural regions. However, the relationship between such sensory mismatch responses and hierarchical predictive processing has not yet been demonstrated at the neuronal level in the auditory pathway. We recorded single-neuron activity from different auditory centers in anaesthetized rats and awake mice while animals were played a sequence of sounds, designed to separate the responses due to prediction error from those due to adaptation effects. Here we report that prediction error is organized hierarchically along the central auditory pathway. These prediction error signals are detectable in subcortical regions and increase as the signals move towards auditory cortex, which in turn demonstrates a large-scale mismatch potential. Finally, the predictive activity of single auditory neurons underlies automatic deviance detection at subcortical levels of processing. These results demonstrate that prediction error is a fundamental component of singly auditory neuron responses.

Suggested Citation

  • Gloria G. Parras & Javier Nieto-Diego & Guillermo V. Carbajal & Catalina Valdés-Baizabal & Carles Escera & Manuel S. Malmierca, 2017. "Neurons along the auditory pathway exhibit a hierarchical organization of prediction error," Nature Communications, Nature, vol. 8(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02038-6
    DOI: 10.1038/s41467-017-02038-6
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    Cited by:

    1. Frank Gelens & Juho Äijälä & Louis Roberts & Misako Komatsu & Cem Uran & Michael A. Jensen & Kai J. Miller & Robin A. A. Ince & Max Garagnani & Martin Vinck & Andres Canales-Johnson, 2024. "Distributed representations of prediction error signals across the cortical hierarchy are synergistic," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Antonino Greco & Julia Moser & Hubert Preissl & Markus Siegel, 2024. "Predictive learning shapes the representational geometry of the human brain," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Keitaro Obara & Teppei Ebina & Shin-Ichiro Terada & Takanori Uka & Misako Komatsu & Masafumi Takaji & Akiya Watakabe & Kenta Kobayashi & Yoshito Masamizu & Hiroaki Mizukami & Tetsuo Yamamori & Kiyoto , 2023. "Change detection in the primate auditory cortex through feedback of prediction error signals," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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