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The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Author

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  • Olli Matilainen

    (École Polytechnique Fédérale de Lausanne
    University of Helsinki)

  • Maroun S. Bou Sleiman

    (École Polytechnique Fédérale de Lausanne)

  • Pedro M. Quiros

    (École Polytechnique Fédérale de Lausanne)

  • Susana M. D. A. Garcia

    (University of Helsinki)

  • Johan Auwerx

    (École Polytechnique Fédérale de Lausanne)

Abstract

Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate disturbance of histone balance during C. elegans development alters histone levels and triggers a stress response associated with increased expression of cytosolic small heat-shock proteins. This stress response is dependent on the transcription factor, HSF-1, and the chromatin remodeling factor, ISW-1. In addition, we show that mitochondrial stress during developmental stages also modulates histone levels, thereby activating a cytosolic stress response similar to that caused by changes in histone balance. These data indicate that histone and mitochondrial perturbations are both monitored through chromatin remodeling and involve the activation of a cytosolic response that affects organismal longevity. HSF-1 and ISW-1 hence emerge as a central mediator of this multi-compartment proteostatic response regulating longevity.

Suggested Citation

  • Olli Matilainen & Maroun S. Bou Sleiman & Pedro M. Quiros & Susana M. D. A. Garcia & Johan Auwerx, 2017. "The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01903-8
    DOI: 10.1038/s41467-017-01903-8
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    Cited by:

    1. Eunah Kim & Andrea Annibal & Yujin Lee & Hae-Eun H. Park & Seokjin Ham & Dae-Eun Jeong & Younghun Kim & Sangsoon Park & Sujeong Kwon & Yoonji Jung & JiSoo Park & Sieun S. Kim & Adam Antebi & Seung-Jae, 2023. "Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Laura Matabishi-Bibi & Drice Challal & Mara Barucco & Domenico Libri & Anna Babour, 2022. "Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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