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Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

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  • Jinsheng Wen

    (Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
    Wenzhou Medical University)

  • Annie Elong Ngono

    (Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology)

  • Jose Angel Regla-Nava

    (Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology)

  • Kenneth Kim

    (Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology)

  • Matthew J. Gorman

    (Washington University School of Medicine)

  • Michael S. Diamond

    (Washington University School of Medicine)

  • Sujan Shresta

    (Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology
    Wenzhou Medical University
    University of California)

Abstract

Zika virus (ZIKV) and dengue virus (DENV) are antigenically related flaviviruses that share cross-reactivity in antibody and T cell responses, and co-circulate in increasing numbers of countries. Whether pre-existing DENV immunity can cross-protect or enhance ZIKV infection during sequential infection of the same host is unknown. Here, we show that DENV-immune Ifnar1 −/− or wild-type C57BL/6 mice infected with ZIKV have cross-reactive immunity to subsequent ZIKV infection and pathogenesis. Adoptive transfer and cell depletion studies demonstrate that DENV-immune CD8+ T cells predominantly mediate cross-protective responses to ZIKV. In contrast, passive transfer studies suggest that DENV-immune serum does not protect against ZIKV infection. Thus, CD8+ T cell immunity generated during primary DENV infection can confer protection against secondary ZIKV infection in mice. Further optimization of current DENV vaccines for T cell responses might confer cross-protection and prevent antibody-mediated enhancement of ZIKV infection.

Suggested Citation

  • Jinsheng Wen & Annie Elong Ngono & Jose Angel Regla-Nava & Kenneth Kim & Matthew J. Gorman & Michael S. Diamond & Sujan Shresta, 2017. "Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01669-z
    DOI: 10.1038/s41467-017-01669-z
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    Cited by:

    1. Rúbens Prince dos Santos Alves & Julia Timis & Robyn Miller & Kristen Valentine & Paolla Beatriz Almeida Pinto & Andrew Gonzalez & Jose Angel Regla-Nava & Erin Maule & Michael N. Nguyen & Norazizah Sh, 2024. "Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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