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Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

Author

Listed:
  • Simon N. Willis

    (1G Royal Parade
    University of Melbourne)

  • Julie Tellier

    (1G Royal Parade
    University of Melbourne)

  • Yang Liao

    (1G Royal Parade
    University of Melbourne)

  • Stephanie Trezise

    (1G Royal Parade
    University of Melbourne)

  • Amanda Light

    (1G Royal Parade)

  • Kristy O’Donnell

    (1G Royal Parade
    Monash University Level 6, Burnet Tower 89 Commercial Road)

  • Lee Ann Garrett-Sinha

    (State University of New York at Buffalo)

  • Wei Shi

    (1G Royal Parade
    University of Melbourne)

  • David M. Tarlinton

    (1G Royal Parade
    University of Melbourne
    Monash University Level 6, Burnet Tower 89 Commercial Road)

  • Stephen L. Nutt

    (1G Royal Parade
    University of Melbourne)

Abstract

Humoral immunity requires B cells to respond to multiple stimuli, including antigen, membrane and soluble ligands, and microbial products. Ets family transcription factors regulate many aspects of haematopoiesis, although their functions in humoral immunity are difficult to decipher as a result of redundancy between the family members. Here we show that mice lacking both PU.1 and SpiB in mature B cells do not generate germinal centers and high-affinity antibody after protein immunization. PU.1 and SpiB double-deficient B cells have a survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhanced plasma cell differentiation. PU.1 and SpiB regulate the expression of many components of the B cell receptor signaling pathway and the receptors for CD40L, BAFF and TLR ligands. Thus, PU.1 and SpiB enable B cells to appropriately respond to environmental cues.

Suggested Citation

  • Simon N. Willis & Julie Tellier & Yang Liao & Stephanie Trezise & Amanda Light & Kristy O’Donnell & Lee Ann Garrett-Sinha & Wei Shi & David M. Tarlinton & Stephen L. Nutt, 2017. "Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01605-1
    DOI: 10.1038/s41467-017-01605-1
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    Cited by:

    1. Yuichi Saito & Akihito Harada & Miho Ushijima & Kaori Tanaka & Ryota Higuchi & Akemi Baba & Daisuke Murakami & Stephen L. Nutt & Takashi Nakagawa & Yasuyuki Ohkawa & Yoshihiro Baba, 2024. "Plasma cell differentiation is regulated by the expression of histone variant H3.3," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Kathryn Weinand & Saori Sakaue & Aparna Nathan & Anna Helena Jonsson & Fan Zhang & Gerald F. M. Watts & Majd Al Suqri & Zhu Zhu & Deepak A. Rao & Jennifer H. Anolik & Michael B. Brenner & Laura T. Don, 2024. "The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-25, December.
    3. JangKeun Kim & Braden T. Tierney & Eliah G. Overbey & Ezequiel Dantas & Matias Fuentealba & Jiwoon Park & S. Anand Narayanan & Fei Wu & Deena Najjar & Christopher R. Chin & Cem Meydan & Conor Loy & Be, 2024. "Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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