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DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress

Author

Listed:
  • Bing Yao

    (Emory University School of Medicine)

  • Ying Cheng

    (Emory University School of Medicine)

  • Zhiqin Wang

    (Central South University)

  • Yujing Li

    (Emory University School of Medicine)

  • Li Chen

    (Emory University School of Medicine
    Harrison School of Pharmacy, Auburn University)

  • Luoxiu Huang

    (Emory University School of Medicine)

  • Wenxin Zhang

    (Chinese Academy of Sciences)

  • Dahua Chen

    (Chinese Academy of Sciences)

  • Hao Wu

    (Emory University School of Public Health)

  • Beisha Tang

    (Central South University)

  • Peng Jin

    (Emory University School of Medicine)

Abstract

Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain unclear. Here we demonstrate 6mA dynamics in the mouse brain in response to environmental stress. We find that overall 6mA levels are significantly elevated upon stress. Genome-wide 6mA and transcriptome profiling reveal an inverse association between 6mA dynamic changes and a set of upregulated neuronal genes or downregulated LINE transposon expression. Genes bearing stress-induced 6mA changes significantly overlap with loci associated with neuropsychiatric disorders. These results suggest an epigenetic role for 6mA in the mammalian brain as well as its potential involvement in neuropsychiatric disorders.

Suggested Citation

  • Bing Yao & Ying Cheng & Zhiqin Wang & Yujing Li & Li Chen & Luoxiu Huang & Wenxin Zhang & Dahua Chen & Hao Wu & Beisha Tang & Peng Jin, 2017. "DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01195-y
    DOI: 10.1038/s41467-017-01195-y
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    Cited by:

    1. Ádám Sturm & Éva Saskői & Bernadette Hotzi & Anna Tarnóci & János Barna & Ferenc Bodnár & Himani Sharma & Tibor Kovács & Eszter Ari & Nóra Weinhardt & Csaba Kerepesi & András Perczel & Zoltán Ivics & , 2023. "Downregulation of transposable elements extends lifespan in Caenorhabditis elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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