IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-01096-0.html
   My bibliography  Save this article

Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease

Author

Listed:
  • Aman P. Mann

    (Sanford Burnham Prebys Medical Discovery Institute)

  • Pablo Scodeller

    (Sanford Burnham Prebys Medical Discovery Institute
    University of Tartu)

  • Sazid Hussain

    (Sanford Burnham Prebys Medical Discovery Institute
    AivoCode Inc.)

  • Gary B. Braun

    (Sanford Burnham Prebys Medical Discovery Institute)

  • Tarmo Mölder

    (University of Tartu)

  • Kadri Toome

    (University of Tartu)

  • Rajesh Ambasudhan

    (Scintillon Institute)

  • Tambet Teesalu

    (University of Tartu)

  • Stuart A. Lipton

    (Scintillon Institute
    University of California, San Diego, School of Medicine)

  • Erkki Ruoslahti

    (Sanford Burnham Prebys Medical Discovery Institute
    University of California, Santa Barbara)

Abstract

Cerebrovascular changes occur in Alzheimer’s disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages. Intravenously injected DAG peptide homes to neurovascular unit endothelial cells and to reactive astrocytes in mouse models of AD. We identified connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the brain of individuals with AD and in mouse models, as the target of the DAG peptide. We also showed that exogenously delivered DAG homes to the brain in mouse models of glioblastoma, traumatic brain injury, and Parkinson’s disease. DAG may potentially be used as a tool to enhance delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation.

Suggested Citation

  • Aman P. Mann & Pablo Scodeller & Sazid Hussain & Gary B. Braun & Tarmo Mölder & Kadri Toome & Rajesh Ambasudhan & Tambet Teesalu & Stuart A. Lipton & Erkki Ruoslahti, 2017. "Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01096-0
    DOI: 10.1038/s41467-017-01096-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-01096-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-01096-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. S. Vickovic & B. Lötstedt & J. Klughammer & S. Mages & Å Segerstolpe & O. Rozenblatt-Rosen & A. Regev, 2022. "SM-Omics is an automated platform for high-throughput spatial multi-omics," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Cao Lu & Cong Meng & Yuying Li & Jinling Yuan & Xiaojun Ren & Liang Gao & Dongdong Su & Kai Cao & Mengchao Cui & Qing Yuan & Xueyun Gao, 2024. "A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01096-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.