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A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF

Author

Listed:
  • Cao Lu

    (Beijing University of Technology)

  • Cong Meng

    (Beijing University of Technology)

  • Yuying Li

    (Beijing Normal University)

  • Jinling Yuan

    (Beijing University of Technology)

  • Xiaojun Ren

    (Beijing University of Technology)

  • Liang Gao

    (Beijing University of Technology)

  • Dongdong Su

    (Beijing University of Technology)

  • Kai Cao

    (Beijing University of Technology)

  • Mengchao Cui

    (Beijing Normal University)

  • Qing Yuan

    (Beijing University of Technology)

  • Xueyun Gao

    (Beijing University of Technology)

Abstract

To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus CTGF could be an earlier diagnostic biomarker of AD than Aβ plaque. Herein, we develop a peptide-coated gold nanocluster that specifically targets CTGF with high affinity (KD ~ 21.9 nM). The probe can well penetrate the blood-brain-barrier (BBB) of APP/PS1 transgenic mice at early-stage (earlier than 3-month-old) in vivo, allowing non-invasive NIR-II imaging of CTGF when there is no appearance of Aβ plaque deposition. Notably, this probe can also be applied to measuring CTGF on postmortem brain sections by multimodal analysis, including fluorescence imaging, peroxidase-like chromogenic imaging, and ICP-MS quantitation, which enables distinguishment between the brains of AD patients and healthy people. This probe possesses great potential for precise diagnosis of earlier AD before Aβ plaque formation.

Suggested Citation

  • Cao Lu & Cong Meng & Yuying Li & Jinling Yuan & Xiaojun Ren & Liang Gao & Dongdong Su & Kai Cao & Mengchao Cui & Qing Yuan & Xueyun Gao, 2024. "A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49409-4
    DOI: 10.1038/s41467-024-49409-4
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    References listed on IDEAS

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    1. Aman P. Mann & Pablo Scodeller & Sazid Hussain & Gary B. Braun & Tarmo Mölder & Kadri Toome & Rajesh Ambasudhan & Tambet Teesalu & Stuart A. Lipton & Erkki Ruoslahti, 2017. "Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer’s disease," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    2. Ani Baghdasaryan & Feifei Wang & Fuqiang Ren & Zhuoran Ma & Jiachen Li & Xueting Zhou & Lilit Grigoryan & Chun Xu & Hongjie Dai, 2022. "Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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