IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-01050-0.html
   My bibliography  Save this article

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Author

Listed:
  • Guangbao Yang

    (Soochow University)

  • Ligeng Xu

    (Soochow University)

  • Yu Chao

    (Soochow University)

  • Jun Xu

    (Soochow University)

  • Xiaoqi Sun

    (Soochow University)

  • Yifan Wu

    (Soochow University)

  • Rui Peng

    (Soochow University)

  • Zhuang Liu

    (Soochow University)

Abstract

Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow structures, H-MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co-loaded with a photodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin (DOX). The obtained H-MnO2-PEG/C&D would be dissociated under reduced pH within TME to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H2O2 to relieve tumor hypoxia. As a result, a remarkable in vivo synergistic therapeutic effect is achieved through the combined chemo-photodynamic therapy, which simultaneously triggers a series of anti-tumor immune responses. Its further combination with checkpoint-blockade therapy would lead to inhibition of tumors at distant sites, promising for tumor metastasis treatment.

Suggested Citation

  • Guangbao Yang & Ligeng Xu & Yu Chao & Jun Xu & Xiaoqi Sun & Yifan Wu & Rui Peng & Zhuang Liu, 2017. "Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01050-0
    DOI: 10.1038/s41467-017-01050-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-01050-0
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-017-01050-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Dongdong Wang & Jiawei Liu & Changlai Wang & Weiyun Zhang & Guangbao Yang & Yun Chen & Xiaodong Zhang & Yinglong Wu & Long Gu & Hongzhong Chen & Wei Yuan & Xiaokai Chen & Guofeng Liu & Bin Gao & Qianw, 2023. "Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Xiaotu Ma & Xiaolong Liang & Meinan Yao & Yu Gao & Qi Luo & Xiaoda Li & Yue Yu & Yining Sun & Miffy H. Y. Cheng & Juan Chen & Gang Zheng & Jiyun Shi & Fan Wang, 2023. "Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Xin Guan & Liping Sun & Yuting Shen & Fengshan Jin & Xiaowan Bo & Chunyan Zhu & Xiaoxia Han & Xiaolong Li & Yu Chen & Huixiong Xu & Wenwen Yue, 2022. "Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Hongwei Lu & An Chen & Xindan Zhang & Zixiang Wei & Rong Cao & Yi Zhu & Jingxiong Lu & Zhongling Wang & Leilei Tian, 2022. "A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Ziyang Cao & Dongdong Li & Liang Zhao & Mengting Liu & Pengyue Ma & Yingli Luo & Xianzhu Yang, 2022. "Bioorthogonal in situ assembly of nanomedicines as drug depots for extracellular drug delivery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01050-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.