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Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy

Author

Listed:
  • Xiaotu Ma

    (Chinese Academy of Sciences
    Peking University Third Hospital)

  • Xiaolong Liang

    (Peking University Third Hospital)

  • Meinan Yao

    (Peking University)

  • Yu Gao

    (Chinese Academy of Sciences)

  • Qi Luo

    (Guangzhou National Laboratory)

  • Xiaoda Li

    (Peking University)

  • Yue Yu

    (Chinese Academy of Sciences)

  • Yining Sun

    (Chinese Academy of Sciences)

  • Miffy H. Y. Cheng

    (University Health Network)

  • Juan Chen

    (University Health Network)

  • Gang Zheng

    (University Health Network
    University of Toronto)

  • Jiyun Shi

    (Chinese Academy of Sciences)

  • Fan Wang

    (Chinese Academy of Sciences
    Peking University
    Guangzhou National Laboratory)

Abstract

Gadolinium (Gd3+)-coordinated texaphyrin (Gd-Tex) is a promising radiosensitizer that entered clinical trials, but temporarily fails largely due to insufficient radiosensitization efficacy. Little attention has been given to using nanovesicles to improve its efficacy. Herein, Gd-Tex is transformed into building blocks “Gd-Tex-lipids” to self-assemble nanovesicles called Gd-nanotexaphyrins (Gd-NTs), realizing high density packing of Gd-Tex in a single nanovesicle and achieving high Gd-Tex accumulation in tumors. To elucidate the impact of O2 concentration on Gd-Tex radiosensitization, myoglobin (Mb) is loaded into Gd-NTs (Mb@Gd-NTs), resulting in efficient relief of tumor hypoxia and significant enhancement of Gd-Tex radiosensitization, eventually inducing the obvious long-term antitumor immune memory to inhibit tumor recurrence. In addition to Gd3+, the versatile Mb@Gd-NTs can also chelate 177Lu3+ (Mb@177Lu/Gd-NTs), enabling SPECT/MRI dual-modality imaging for accurately monitoring drug delivery in real-time. This “one-for-all” nanoplatform with the capability of chelating various trivalent metal ions exhibits broad clinical application prospects in imaging-guided radiosensitization therapy.

Suggested Citation

  • Xiaotu Ma & Xiaolong Liang & Meinan Yao & Yu Gao & Qi Luo & Xiaoda Li & Yue Yu & Yining Sun & Miffy H. Y. Cheng & Juan Chen & Gang Zheng & Jiyun Shi & Fan Wang, 2023. "Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosensitization therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41782-w
    DOI: 10.1038/s41467-023-41782-w
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    References listed on IDEAS

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    1. Guangbao Yang & Ligeng Xu & Yu Chao & Jun Xu & Xiaoqi Sun & Yifan Wu & Rui Peng & Zhuang Liu, 2017. "Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
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