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Ets transcription factor GABP controls T cell homeostasis and immunity

Author

Listed:
  • Chong T. Luo

    (Memorial Sloan Kettering Cancer Center
    Memorial Sloan Kettering Cancer Center)

  • Hatice U. Osmanbeyoglu

    (Memorial Sloan Kettering Cancer Center)

  • Mytrang H. Do

    (Memorial Sloan Kettering Cancer Center)

  • Michael R. Bivona

    (Memorial Sloan Kettering Cancer Center)

  • Ahmed Toure

    (Memorial Sloan Kettering Cancer Center)

  • Davina Kang

    (Memorial Sloan Kettering Cancer Center)

  • Yuchen Xie

    (Memorial Sloan Kettering Cancer Center)

  • Christina S. Leslie

    (Memorial Sloan Kettering Cancer Center)

  • Ming O. Li

    (Memorial Sloan Kettering Cancer Center)

Abstract

Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.

Suggested Citation

  • Chong T. Luo & Hatice U. Osmanbeyoglu & Mytrang H. Do & Michael R. Bivona & Ahmed Toure & Davina Kang & Yuchen Xie & Christina S. Leslie & Ming O. Li, 2017. "Ets transcription factor GABP controls T cell homeostasis and immunity," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01020-6
    DOI: 10.1038/s41467-017-01020-6
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    Cited by:

    1. Xinran Dong & Liang Ding & Andrew Thrasher & Xinge Wang & Jingjing Liu & Qingfei Pan & Jordan Rash & Yogesh Dhungana & Xu Yang & Isabel Risch & Yuxin Li & Lei Yan & Michael Rusch & Clay McLeod & Koon-, 2023. "NetBID2 provides comprehensive hidden driver analysis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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