IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-00985-8.html
   My bibliography  Save this article

Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Author

Listed:
  • Alexandros Glentis

    (PSL Research University)

  • Philipp Oertle

    (University of Basel)

  • Pascale Mariani

    (Curie Institute)

  • Aleksandra Chikina

    (PSL Research University)

  • Fatima El Marjou

    (PSL Research University)

  • Youmna Attieh

    (PSL Research University)

  • Francois Zaccarini

    (PSL Research University)

  • Marick Lae

    (Curie Institute)

  • Damarys Loew

    (PSL Research University, Laboratoire de spectrométrie de masse protéomique)

  • Florent Dingli

    (PSL Research University, Laboratoire de spectrométrie de masse protéomique)

  • Philemon Sirven

    (Institut Curie, PSL Research University)

  • Marie Schoumacher

    (PSL Research University)

  • Basile G. Gurchenkov

    (PSL Research University)

  • Marija Plodinec

    (University of Basel
    University Hospital Basel)

  • Danijela Matic Vignjevic

    (PSL Research University)

Abstract

At the stage of carcinoma in situ, the basement membrane (BM) segregates tumor cells from the stroma. This barrier must be breached to allow dissemination of the tumor cells to adjacent tissues. Cancer cells can perforate the BM using proteolysis; however, whether stromal cells play a role in this process remains unknown. Here we show that an abundant stromal cell population, cancer-associated fibroblasts (CAFs), promote cancer cell invasion through the BM. CAFs facilitate the breaching of the BM in a matrix metalloproteinase-independent manner. Instead, CAFs pull, stretch, and soften the BM leading to the formation of gaps through which cancer cells can migrate. By exerting contractile forces, CAFs alter the organization and the physical properties of the BM, making it permissive for cancer cell invasion. Blocking the ability of stromal cells to exert mechanical forces on the BM could therefore represent a new therapeutic strategy against aggressive tumors.

Suggested Citation

  • Alexandros Glentis & Philipp Oertle & Pascale Mariani & Aleksandra Chikina & Fatima El Marjou & Youmna Attieh & Francois Zaccarini & Marick Lae & Damarys Loew & Florent Dingli & Philemon Sirven & Mari, 2017. "Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00985-8
    DOI: 10.1038/s41467-017-00985-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-00985-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-00985-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jorge Barbazan & Carlos Pérez-González & Manuel Gómez-González & Mathieu Dedenon & Sophie Richon & Ernest Latorre & Marco Serra & Pascale Mariani & Stéphanie Descroix & Pierre Sens & Xavier Trepat & D, 2023. "Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Julian C. Bahr & Xiao-Yan Li & Tamar Y. Feinberg & Long Jiang & Stephen J. Weiss, 2022. "Divergent regulation of basement membrane trafficking by human macrophages and cancer cells," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00985-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.