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A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials

Author

Listed:
  • Lamia L. G. Al-Mahamad

    (Newcastle University
    Al-Mustansiriya University)

  • Osama El-Zubir

    (Newcastle University)

  • David G. Smith

    (Newcastle University
    University of Sydney)

  • Benjamin R. Horrocks

    (Newcastle University)

  • Andrew Houlton

    (Newcastle University)

Abstract

Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside. The complexation reaction with Au(I) ions spontaneously assembles luminescent one-dimensional helical chains, characterized as {AuI(μ-6-TG)} n , extending many μm in length that are structurally analogous to natural DNA. Uniquely, for such a material, this gold-thiolate can be transformed into a wire-like conducting form by oxidative doping. We also show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconducting sequences, site-specifically, into the framework of DNA materials, transforming their properties in a fundamental and technologically useful manner.

Suggested Citation

  • Lamia L. G. Al-Mahamad & Osama El-Zubir & David G. Smith & Benjamin R. Horrocks & Andrew Houlton, 2017. "A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00852-6
    DOI: 10.1038/s41467-017-00852-6
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    Cited by:

    1. Uroš Javornik & Antonio Pérez-Romero & Carmen López-Chamorro & Rachelle M. Smith & José A. Dobado & Oscar Palacios & Mrinal K. Bera & May Nyman & Janez Plavec & Miguel A. Galindo, 2024. "Unveiling the solution structure of a DNA duplex with continuous silver-modified Watson-Crick base pairs," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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