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Laminar differences in decision-related neural activity in dorsal premotor cortex

Author

Listed:
  • Chandramouli Chandrasekaran

    (Stanford University)

  • Diogo Peixoto

    (Stanford University
    Champalimaud Neuroscience Programme)

  • William T. Newsome

    (Stanford University
    Stanford University
    Stanford University)

  • Krishna V. Shenoy

    (Stanford University
    Stanford University
    Stanford University
    Stanford University)

Abstract

Dorsal premotor cortex is implicated in somatomotor decisions. However, we do not understand the temporal patterns and laminar organization of decision-related firing rates in dorsal premotor cortex. We recorded neurons from dorsal premotor cortex of monkeys performing a visual discrimination task with reaches as the behavioral report. We show that these neurons can be organized along a bidirectional visuomotor continuum based on task-related firing rates. “Increased” neurons at one end of the continuum increased their firing rates ~150 ms after stimulus onset and these firing rates covaried systematically with choice, stimulus difficulty, and reaction time—characteristics of a candidate decision variable. “Decreased” neurons at the other end of the continuum reduced their firing rate after stimulus onset, while “perimovement” neurons at the center of the continuum responded only ~150 ms before movement initiation. These neurons did not show decision variable-like characteristics. “Increased” neurons were more prevalent in superficial layers of dorsal premotor cortex; deeper layers contained more “decreased” and “perimovement” neurons. These results suggest a laminar organization for decision-related responses in dorsal premotor cortex.

Suggested Citation

  • Chandramouli Chandrasekaran & Diogo Peixoto & William T. Newsome & Krishna V. Shenoy, 2017. "Laminar differences in decision-related neural activity in dorsal premotor cortex," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00715-0
    DOI: 10.1038/s41467-017-00715-0
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    Cited by:

    1. Pierre O. Boucher & Tian Wang & Laura Carceroni & Gary Kane & Krishna V. Shenoy & Chandramouli Chandrasekaran, 2023. "Initial conditions combine with sensory evidence to induce decision-related dynamics in premotor cortex," Nature Communications, Nature, vol. 14(1), pages 1-28, December.
    2. Mikhail Genkin & Owen Hughes & Tatiana A. Engel, 2021. "Learning non-stationary Langevin dynamics from stochastic observations of latent trajectories," Nature Communications, Nature, vol. 12(1), pages 1-9, December.

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