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Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Author

Listed:
  • Yosuke M. Morizawa

    (University of Yamanashi
    Tohoku University)

  • Yuri Hirayama

    (University of Yamanashi)

  • Nobuhiko Ohno

    (National Institute for Physiological Sciences)

  • Shinsuke Shibata

    (Keio University School of Medicine)

  • Eiji Shigetomi

    (University of Yamanashi)

  • Yang Sui

    (National Institute for Physiological Sciences)

  • Junichi Nabekura

    (National Institute for Physiological Sciences
    The Graduate School for Advanced Study)

  • Koichi Sato

    (Gunma University)

  • Fumikazu Okajima

    (Gunma University)

  • Hirohide Takebayashi

    (Niigata University)

  • Hideyuki Okano

    (Keio University School of Medicine)

  • Schuichi Koizumi

    (University of Yamanashi)

Abstract

Astrocytes become reactive following various brain insults; however, the functions of reactive astrocytes are poorly understood. Here, we show that reactive astrocytes function as phagocytes after transient ischemic injury and appear in a limited spatiotemporal pattern. Following transient brain ischemia, phagocytic astrocytes are observed within the ischemic penumbra region during the later stage of ischemia. However, phagocytic microglia are mainly observed within the ischemic core region during the earlier stage of ischemia. Phagocytic astrocytes upregulate ABCA1 and its pathway molecules, MEGF10 and GULP1, which are required for phagocytosis, and upregulation of ABCA1 alone is sufficient for enhancement of phagocytosis in vitro. Disrupting ABCA1 in reactive astrocytes result in fewer phagocytic inclusions after ischemia. Together, these findings suggest that astrocytes are transformed into a phagocytic phenotype as a result of increase in ABCA1 and its pathway molecules and contribute to remodeling of damaged tissues and penumbra networks.

Suggested Citation

  • Yosuke M. Morizawa & Yuri Hirayama & Nobuhiko Ohno & Shinsuke Shibata & Eiji Shigetomi & Yang Sui & Junichi Nabekura & Koichi Sato & Fumikazu Okajima & Hirohide Takebayashi & Hideyuki Okano & Schuichi, 2017. "Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00037-1
    DOI: 10.1038/s41467-017-00037-1
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    Cited by:

    1. Tian Zhou & Yuxin Li & Xiaoyu Li & Fanzhuo Zeng & Yanxia Rao & Yang He & Yafei Wang & Meizhen Liu & Dali Li & Zhen Xu & Xin Zhou & Siling Du & Fugui Niu & Jiyun Peng & Xifan Mei & Sheng-Jian Ji & Yous, 2022. "Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Xiaojing Shi & Longlong Luo & Jixian Wang & Hui Shen & Yongfang Li & Muyassar Mamtilahun & Chang Liu & Rubing Shi & Joon-Hyuk Lee & Hengli Tian & Zhijun Zhang & Yongting Wang & Won-Suk Chung & Yaohui , 2021. "Stroke subtype-dependent synapse elimination by reactive gliosis in mice," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    3. Ting Wan & Wusheng Zhu & Ying Zhao & Xiaohao Zhang & Ruidong Ye & Meng Zuo & Pengfei Xu & Zhenqian Huang & Chunni Zhang & Yi Xie & Xinfeng Liu, 2022. "Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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