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Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

Author

Listed:
  • Sara M. Willems

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Daniel J. Wright

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Felix R. Day

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Katerina Trajanoska

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Peter K. Joshi

    (Usher Institute for Population Health Sciences and Informatics, University of Edinburgh)

  • John A. Morris

    (Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
    McGill University)

  • Amy M. Matteini

    (Johns Hopkins University School of Medicine)

  • Fleur C. Garton

    (Queensland Brain Institute, University of Queensland)

  • Niels Grarup

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Nikolay Oskolkov

    (Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital)

  • Anbupalam Thalamuthu

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales)

  • Massimo Mangino

    (Kings College London
    NIHR Biomedical Research Centre at Guy’s and St. Thomas’ NHS Foundation Trust)

  • Jun Liu

    (Erasmus Medical Center)

  • Ayse Demirkan

    (Erasmus Medical Center
    Leiden University Medical Center)

  • Monkol Lek

    (Analytic and Translational Genetics Unit, Massachusetts General Hospital
    Harvard Medical School)

  • Liwen Xu

    (Analytic and Translational Genetics Unit, Massachusetts General Hospital
    Harvard Medical School)

  • Guan Wang

    (Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton)

  • Christopher Oldmeadow

    (Hunter Medical Research Institute)

  • Kyle J. Gaulton

    (University of California San Diego)

  • Luca A. Lotta

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Eri Miyamoto-Mikami

    (Japan Society for the Promotion of Science
    National Institute of Fitness and Sports)

  • Manuel A. Rivas

    (Stanford University
    BROAD Institute of the Massachusetts Institute of Technology and Harvard University)

  • Tom White

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Po-Ru Loh

    (BROAD Institute of the Massachusetts Institute of Technology and Harvard University
    Harvard T.H. Chan School of Public Health)

  • Mette Aadahl

    (Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital)

  • Najaf Amin

    (Erasmus Medical Center)

  • John R. Attia

    (Hunter Medical Research Institute
    Faculty of Health and Medicine, University of Newcastle
    John Hunter Hospital)

  • Krista Austin

    (Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton)

  • Beben Benyamin

    (Queensland Brain Institute, University of Queensland
    Institute for Molecular Bioscience, University of Queensland)

  • Søren Brage

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Yu-Ching Cheng

    (University of Maryland School of Medicine)

  • Paweł Cięszczyk

    (Faculty of Physical Education, Gdańsk University of Physical Education and Sport)

  • Wim Derave

    (Ghent University)

  • Karl-Fredrik Eriksson

    (Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital)

  • Nir Eynon

    (Institute of Sport, Exercise & Active Living (ISEAL), Victoria University
    Murdoch Children’s Research Institute, Royal Children’s Hospital)

  • Allan Linneberg

    (Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital
    Department of Clinical Experimental Research
    Faculty of Health and Medical Sciences, University of Copenhagen)

  • Alejandro Lucia

    (Universidad Europea de Madrid
    Research Institute ‘i+12’, Hospital Universitario 12 de Octubre)

  • Myosotis Massidda

    (University of Cagliari)

  • Braxton D. Mitchell

    (University of Maryland School of Medicine
    Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center)

  • Motohiko Miyachi

    (National Institutes of Biomedical Innovation, Health and Nutrition)

  • Haruka Murakami

    (National Institutes of Biomedical Innovation, Health and Nutrition)

  • Sandosh Padmanabhan

    (British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow)

  • Ashutosh Pandey

    (Target Sciences, GlaxoSmithKline)

  • Ioannis Papadimitriou

    (Institute of Sport, Exercise & Active Living (ISEAL), Victoria University)

  • Deepak K. Rajpal

    (Target Sciences, GlaxoSmithKline)

  • Craig Sale

    (Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University)

  • Theresia M. Schnurr

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Francesco Sessa

    (Medical Genetics, University of Foggia)

  • Nick Shrine

    (University of Leicester
    National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital)

  • Martin D. Tobin

    (University of Leicester
    National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital)

  • Ian Varley

    (Musculoskeletal Physiology Research Group, Sport, Health and Performance Enhancement (SHAPE) Research Centre, Nottingham Trent University)

  • Louise V. Wain

    (University of Leicester
    National Institute for Health Research, Leicester Respiratory Biomedical Research Unit, Glenfield Hospital)

  • Naomi R. Wray

    (Queensland Brain Institute, University of Queensland
    Institute for Molecular Bioscience, University of Queensland)

  • Cecilia M. Lindgren

    (BROAD Institute of the Massachusetts Institute of Technology and Harvard University
    The Big Data Institute, University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Daniel G. MacArthur

    (Analytic and Translational Genetics Unit, Massachusetts General Hospital
    BROAD Institute of the Massachusetts Institute of Technology and Harvard University)

  • Dawn M. Waterworth

    (Target Sciences, GlaxoSmithKline)

  • Mark I. McCarthy

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
    NIHR Oxford Biomedical Research Centre)

  • Oluf Pedersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Douglas P. Kiel

    (Harvard Medical School
    Institute for Aging Research, Hebrew SeniorLife
    Beth Israel Deaconess Medical Centre)

  • Yannis Pitsiladis

    (Centre for Sport and Exercise Science and Medicine (SESAME), University of Brighton)

  • Noriyuki Fuku

    (Graduate School of Health and Sports Science, Juntendo University)

  • Paul W. Franks

    (Genetic and Molecular Epidemiology Unit, Lund University, Skånes University Hospital
    Public Health and Clinical Medicine, Section for Medicine, Umeå University
    Biobank Research, Umeå University)

  • Kathryn N. North

    (Murdoch Children’s Research Institute, Royal Children’s Hospital)

  • Cornelia M. van Duijn

    (Erasmus Medical Center)

  • Karen A. Mather

    (Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales)

  • Torben Hansen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Health Sciences, University of Southern Denmark)

  • Ola Hansson

    (Lund University Diabetes Center, Diabetes and Endocrinology, Skånes University Hospital)

  • Tim Spector

    (Kings College London)

  • Joanne M. Murabito

    (Boston University School of Medicine, Section of General Internal Medicine
    National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study)

  • J. Brent Richards

    (Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University
    McGill University
    Kings College London
    McGill University)

  • Fernando Rivadeneira

    (Erasmus Medical Center
    Erasmus Medical Center)

  • Claudia Langenberg

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • John R. B. Perry

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Nick J. Wareham

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

  • Robert A. Scott

    (MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine)

Abstract

Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P

Suggested Citation

  • Sara M. Willems & Daniel J. Wright & Felix R. Day & Katerina Trajanoska & Peter K. Joshi & John A. Morris & Amy M. Matteini & Fleur C. Garton & Niels Grarup & Nikolay Oskolkov & Anbupalam Thalamuthu &, 2017. "Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16015
    DOI: 10.1038/ncomms16015
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    Cited by:

    1. Yunfeng Huang & Dora Bodnar & Chia-Yen Chen & Gabriela Sanchez-Andrade & Mark Sanderson & Jun Shi & Katherine G. Meilleur & Matthew E. Hurles & Sebastian S. Gerety & Ellen A. Tsai & Heiko Runz, 2023. "Rare genetic variants impact muscle strength," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Maria Niarchou & Daniel E. Gustavson & J. Fah Sathirapongsasuti & Manuel Anglada-Tort & Else Eising & Eamonn Bell & Evonne McArthur & Peter Straub & J. Devin McAuley & John A. Capra & Fredrik Ullén & , 2022. "Genome-wide association study of musical beat synchronization demonstrates high polygenicity," Nature Human Behaviour, Nature, vol. 6(9), pages 1292-1309, September.

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