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Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT

Author

Listed:
  • Harumi Saito

    (Faculty of Medical Sciences, University of Fukui)

  • Hirofumi Nishizumi

    (Faculty of Medical Sciences, University of Fukui
    Graduate School of Science, The University of Tokyo)

  • Satoshi Suzuki

    (Graduate School of Science, The University of Tokyo)

  • Hideyuki Matsumoto

    (Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo)

  • Nao Ieki

    (Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo)

  • Takaya Abe

    (Genetic Engineering Team, RIKEN, Center for Life Science Technologies)

  • Hiroshi Kiyonari

    (Genetic Engineering Team, RIKEN, Center for Life Science Technologies
    Animal Resource Development Unit, RIKEN, Center for Life Science Technologies)

  • Masahiko Morita

    (Image Processing Research Team, RIKEN)

  • Hideo Yokota

    (Image Processing Research Team, RIKEN)

  • Nozomi Hirayama

    (School of Veterinary Medicine, Azabu University)

  • Takahiro Yamazaki

    (Faculty of Medical Sciences, University of Fukui)

  • Takefumi Kikusui

    (School of Veterinary Medicine, Azabu University)

  • Kensaku Mori

    (Cellular and Molecular Physiology, Graduate School of Medicine, The University of Tokyo)

  • Hitoshi Sakano

    (Faculty of Medical Sciences, University of Fukui)

Abstract

Fox odour 2,4,5-trimethyl thiazoline (TMT) is known to activate multiple glomeruli in the mouse olfactory bulb (OB) and elicits strong fear responses. In this study, we screened TMT-reactive odourant receptors and identified Olfr1019 with high ligand reactivity and selectivity, whose glomeruli are located in the posterodorsal OB. In the channelrhodopsin knock-in mice for Olfr1019, TMT-responsive olfactory-cortical regions were activated by photostimulation, leading to the induction of immobility, but not aversive behaviour. Distribution of photoactivation signals was overlapped with that of TMT-induced signals, but restricted to the narrower regions. In the knockout mice, immobility responses were reduced, but not entirely abolished likely due to the compensatory function of other TMT-responsive glomeruli. Our results demonstrate that the activation of a single glomerular species in the posterodorsal OB is sufficient to elicit immobility responses and that TMT-induced fear may be separated into at least two different components of immobility and aversion.

Suggested Citation

  • Harumi Saito & Hirofumi Nishizumi & Satoshi Suzuki & Hideyuki Matsumoto & Nao Ieki & Takaya Abe & Hiroshi Kiyonari & Masahiko Morita & Hideo Yokota & Nozomi Hirayama & Takahiro Yamazaki & Takefumi Kik, 2017. "Immobility responses are induced by photoactivation of single glomerular species responsive to fox odour TMT," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16011
    DOI: 10.1038/ncomms16011
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    Cited by:

    1. Kevin W. Zhu & Shawn D. Burton & Maira H. Nagai & Justin D. Silverman & Claire A. March & Matt Wachowiak & Hiroaki Matsunami, 2022. "Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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