Author
Listed:
- Kalpana Makhijani
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Brandy Alexander
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Deepti Rao
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Sophia Petraki
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Leire Herboso
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Katelyn Kukar
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Itrat Batool
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Stephanie Wachner
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Present address: Institute of Science and Technology (IST) Austria, 3400 Klosterneuburg, Austria)
- Katrina S. Gold
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Corinna Wong
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco)
- Michael B. O’Connor
(Cell Biology and Development, University of Minnesota)
- Katja Brückner
(Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco
Cardiovascular Research Institute, and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco)
Abstract
An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined.
Suggested Citation
Kalpana Makhijani & Brandy Alexander & Deepti Rao & Sophia Petraki & Leire Herboso & Katelyn Kukar & Itrat Batool & Stephanie Wachner & Katrina S. Gold & Corinna Wong & Michael B. O’Connor & Katja Brü, 2017.
"Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons,"
Nature Communications, Nature, vol. 8(1), pages 1-12, December.
Handle:
RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15990
DOI: 10.1038/ncomms15990
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Cited by:
- Hsin-Ho Sung & Hsun Li & Yi-Chun Huang & Chun-Lu Ai & Ming-Yen Hsieh & Hau-Ming Jan & Yu-Ju Peng & Hsien-Ya Lin & Chih-Hsuan Yeh & Shu-Yu Lin & Chun-Yen Yeh & Ying-Ju Cheng & Kay-Hooi Khoo & Chun-Hung, 2024.
"Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning,"
Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Christian F. Christensen & Quentin Laurichesse & Rihab Loudhaief & Julien Colombani & Ditte S. Andersen, 2024.
"Drosophila activins adapt gut size to food intake and promote regenerative growth,"
Nature Communications, Nature, vol. 15(1), pages 1-12, December.
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