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A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion

Author

Listed:
  • Yuwei Jiang

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Daniel C. Berry

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

  • Ayoung Jo

    (University of Texas Southwestern Medical Center)

  • Wei Tang

    (University of Texas Southwestern Medical Center)

  • Robert W. Arpke

    (Lillehei Heart Institute, University of Minnesota
    University of Minnesota)

  • Michael Kyba

    (Lillehei Heart Institute, University of Minnesota
    University of Minnesota)

  • Jonathan M. Graff

    (University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical Center)

Abstract

Adipose progenitor cells (APCs) reside in a vascular niche, located within the perivascular compartment of adipose tissue blood vessels. Yet, the signals and mechanisms that govern adipose vascular niche formation and APC niche interaction are unknown. Here we show that the assembly and maintenance of the adipose vascular niche is controlled by PPARγ acting within APCs. PPARγ triggers a molecular hierarchy that induces vascular sprouting, APC vessel niche affinity and APC vessel occupancy. Mechanistically, PPARγ transcriptionally activates PDGFRβ and VEGF. APC expression and activation of PDGFRβ promotes the recruitment and retention of APCs to the niche. Pharmacologically, targeting PDGFRβ disrupts APC niche contact thus blocking adipose tissue expansion. Moreover, enhanced APC expression of VEGF stimulates endothelial cell proliferation and expands the adipose niche. Consequently, APC niche communication and retention are boosted by VEGF thereby impairing adipogenesis. Our data indicate that APCs direct adipose tissue niche expansion via a PPARγ-initiated PDGFRβ and VEGF transcriptional axis.

Suggested Citation

  • Yuwei Jiang & Daniel C. Berry & Ayoung Jo & Wei Tang & Robert W. Arpke & Michael Kyba & Jonathan M. Graff, 2017. "A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion," Nature Communications, Nature, vol. 8(1), pages 1-16, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15926
    DOI: 10.1038/ncomms15926
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    Cited by:

    1. Benjamin M. Steiner & Abigail M. Benvie & Derek Lee & Yuwei Jiang & Daniel C. Berry, 2024. "Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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