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Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

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  • Anand Patwardhan

    (Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments)

  • Sabine Bardin

    (Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport)

  • Stéphanie Miserey-Lenkei

    (Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport)

  • Lionel Larue

    (Institut Curie, PSL Research University, INSERM U1021, Normal and Pathological Development of Melanocytes
    Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3347
    Equipe Labellisée Ligue Contre le Cancer)

  • Bruno Goud

    (Institut Curie, PSL Research University, CNRS, UMR 144, Molecular Mechanisms of Intracellular Transport)

  • Graça Raposo

    (Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
    Institut Curie, PSL Research University, CNRS, UMR144, Cell and Tissue Imaging Facility (PICT-IBiSA))

  • Cédric Delevoye

    (Institut Curie, PSL Research University, CNRS, UMR 144, Structure and Membrane Compartments
    Institut Curie, PSL Research University, CNRS, UMR144, Cell and Tissue Imaging Facility (PICT-IBiSA))

Abstract

Exocytic carriers convey neo-synthesized components from the Golgi apparatus to the cell surface. While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking of secretory vesicles to particular areas of the plasma membrane. Here, we show that specialized cell types exploit and divert the secretory pathway towards lysosome related organelles. In cultured melanocytes, the secretory route relies on RAB6 and ELKS to directly transport and dock Golgi-derived carriers to melanosomes. By delivering specific cargos, such as MART-1 and TYRP2/ DCT, the RAB6/ELKS-dependent secretory pathway controls the formation and maturation of melanosomes but also pigment synthesis. In addition, pigmentation defects are observed in RAB6 KO mice. Our data together reveal for the first time that the secretory pathway can be directed towards intracellular organelles of endosomal origin to ensure their biogenesis and function.

Suggested Citation

  • Anand Patwardhan & Sabine Bardin & Stéphanie Miserey-Lenkei & Lionel Larue & Bruno Goud & Graça Raposo & Cédric Delevoye, 2017. "Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15835
    DOI: 10.1038/ncomms15835
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