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Spaser as a biological probe

Author

Listed:
  • Ekaterina I. Galanzha

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Robert Weingold

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Dmitry A. Nedosekin

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Mustafa Sarimollaoglu

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Jacqueline Nolan

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Walter Harrington

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

  • Alexander S. Kuchyanov

    (Institute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Science)

  • Roman G. Parkhomenko

    (Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Science)

  • Fumiya Watanabe

    (Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock)

  • Zeid Nima

    (Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock)

  • Alexandru S. Biris

    (Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock)

  • Alexander I. Plekhanov

    (Institute of Automation and Electrometry of the Siberian Branch of the Russian Academy of Science)

  • Mark I. Stockman

    (Georgia State University)

  • Vladimir P. Zharov

    (Arkansas Nanomedicine Center, University of Arkansas for Medical Sciences)

Abstract

Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of generating stimulated emission directly inside living cells and animal tissues. We have demonstrated a lasing regime associated with the formation of a dynamic vapour nanobubble around the spaser that leads to giant spasing with emission intensity and spectral width >100 times brighter and 30-fold narrower, respectively, than for quantum dots. The absorption losses in the spaser enhance its multifunctionality, allowing for nanobubble-amplified photothermal and photoacoustic imaging and therapy. Furthermore, the silica spaser surface has been covalently functionalized with folic acid for molecular targeting of cancer cells. All these properties make a nanobubble spaser a promising multimodal, super-contrast, ultrafast cellular probe with a single-pulse nanosecond excitation for a variety of in vitro and in vivo biomedical applications.

Suggested Citation

  • Ekaterina I. Galanzha & Robert Weingold & Dmitry A. Nedosekin & Mustafa Sarimollaoglu & Jacqueline Nolan & Walter Harrington & Alexander S. Kuchyanov & Roman G. Parkhomenko & Fumiya Watanabe & Zeid Ni, 2017. "Spaser as a biological probe," Nature Communications, Nature, vol. 8(1), pages 1-7, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15528
    DOI: 10.1038/ncomms15528
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    Cited by:

    1. Aljaž Kavčič & Maja Garvas & Matevž Marinčič & Katrin Unger & Anna Maria Coclite & Boris Majaron & Matjaž Humar, 2022. "Deep tissue localization and sensing using optical microcavity probes," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Piotr Piotrowski & Marta Buza & Rafał Nowaczyński & Nuttawut Kongsuwan & Hańcza B. Surma & Paweł Osewski & Marcin Gajc & Adam Strzep & Witold Ryba-Romanowski & Ortwin Hess & Dorota A. Pawlak, 2024. "Ultrafast photoluminescence and multiscale light amplification in nanoplasmonic cavity glass," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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