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Neuronal control of peripheral insulin sensitivity and glucose metabolism

Author

Listed:
  • Johan Ruud

    (Max Planck Institute for Metabolism Research
    Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne
    Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Sophie M. Steculorum

    (Max Planck Institute for Metabolism Research
    Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne
    Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Jens C. Brüning

    (Max Planck Institute for Metabolism Research
    Policlinic for Endocrinology, Diabetes and Preventive Medicine (PEDP), University Hospital Cologne
    Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne
    National Center for Diabetes Research (DZD))

Abstract

The central nervous system (CNS) has an important role in the regulation of peripheral insulin sensitivity and glucose homeostasis. Research in this dynamically developing field has progressed rapidly due to techniques allowing targeted transgenesis and neurocircuitry mapping, which have defined the primary responsive neurons, associated molecular mechanisms and downstream neurocircuitries and processes involved. Here we review the brain regions, neurons and molecular mechanisms by which the CNS controls peripheral glucose metabolism, particularly via regulation of liver, brown adipose tissue and pancreatic function, and highlight the potential implications of these regulatory pathways in type 2 diabetes and obesity.

Suggested Citation

  • Johan Ruud & Sophie M. Steculorum & Jens C. Brüning, 2017. "Neuronal control of peripheral insulin sensitivity and glucose metabolism," Nature Communications, Nature, vol. 8(1), pages 1-12, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15259
    DOI: 10.1038/ncomms15259
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    Cited by:

    1. Virginia Kimonis & Abhilasha Surampalli & Marie Wencel & June-Anne Gold & Neil M Cowen, 2019. "A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-20, September.
    2. Yuhao Huang & Jeffrey B. Wang & Jonathon J. Parker & Rajat Shivacharan & Rayhan A. Lal & Casey H. Halpern, 2023. "Spectro-spatial features in distributed human intracranial activity proactively encode peripheral metabolic activity," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Philipp Hammerschmidt & Sophie M. Steculorum & Cécile L. Bandet & Almudena Río-Martín & Lukas Steuernagel & Vivien Kohlhaas & Marvin Feldmann & Luis Varela & Adam Majcher & Marta Quatorze Correia & Rh, 2023. "CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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