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Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation

Author

Listed:
  • Xiang Qin

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS)

  • Byung Ouk Park

    (Center for Cognition and Sociality, Institute for Basic Science (IBS))

  • Jiaying Liu

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS)

  • Bing Chen

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS
    Southwest Hospital, Third Military Medical University)

  • Valerie Choesmel-Cadamuro

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS)

  • Karine Belguise

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS)

  • Won Do Heo

    (Center for Cognition and Sociality, Institute for Basic Science (IBS)
    Korea Advanced Institute of Science and Technology (KAIST))

  • Xiaobo Wang

    (LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS)

Abstract

Pulsatile actomyosin contractility, important in tissue morphogenesis, has been studied mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber elongation is regulated by both cell–matrix and cell–cell adhesions. However, the mechanism by which these two adhesions govern basal myosin oscillation and tissue elongation is unknown. Here we demonstrate that cell–matrix adhesion positively regulates basal junctional Rho1 activity and medio-basal ROCK and myosin activities, thus strongly controlling tissue elongation. Differently, cell–cell adhesion governs basal myosin oscillation through controlling medio-basal distributions of both ROCK and myosin signals, which are related to the spatial limitations of cell–matrix adhesion and stress fibres. Contrary to cell–matrix adhesion, cell–cell adhesion weakly affects tissue elongation. In vivo optogenetic protein inhibition spatiotemporally confirms the different effects of these two adhesions on basal myosin oscillation. This study highlights the activity and distribution controls of basal myosin contractility mediated by cell–matrix and cell–cell adhesions, respectively, during tissue morphogenesis.

Suggested Citation

  • Xiang Qin & Byung Ouk Park & Jiaying Liu & Bing Chen & Valerie Choesmel-Cadamuro & Karine Belguise & Won Do Heo & Xiaobo Wang, 2017. "Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation," Nature Communications, Nature, vol. 8(1), pages 1-16, April.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14708
    DOI: 10.1038/ncomms14708
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    Cited by:

    1. Shun Li & Zong-Yuan Liu & Hao Li & Sijia Zhou & Jiaying Liu & Ningwei Sun & Kai-Fu Yang & Vanessa Dougados & Thomas Mangeat & Karine Belguise & Xi-Qiao Feng & Yiyao Liu & Xiaobo Wang, 2024. "Basal actomyosin pulses expand epithelium coordinating cell flattening and tissue elongation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Zheng Zhang & Baoyong Sha & Lingzhu Zhao & Huan Zhang & Jinteng Feng & Cheng Zhang & Lin Sun & Meiqing Luo & Bin Gao & Hui Guo & Zheng Wang & Feng Xu & Tian Jian Lu & Guy M. Genin & Min Lin, 2022. "Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Alexis Villars & Alexis Matamoro-Vidal & Florence Levillayer & Romain Levayer, 2022. "Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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