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Defining stem cell dynamics and migration during wound healing in mouse skin epidermis

Author

Listed:
  • Mariaceleste Aragona

    (Université Libre de Bruxelles, IRIBHM)

  • Sophie Dekoninck

    (Université Libre de Bruxelles, IRIBHM)

  • Steffen Rulands

    (Cavendish Laboratory, University of Cambridge)

  • Sandrine Lenglez

    (Université Libre de Bruxelles, IRIBHM)

  • Guilhem Mascré

    (Université Libre de Bruxelles, IRIBHM)

  • Benjamin D. Simons

    (Cavendish Laboratory, University of Cambridge
    The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge)

  • Cédric Blanpain

    (Université Libre de Bruxelles, IRIBHM
    WELBIO, Université Libre de Bruxelles)

Abstract

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitors that expand and repair the wound. These results have important implications for tissue regeneration, acute and chronic wound disorders.

Suggested Citation

  • Mariaceleste Aragona & Sophie Dekoninck & Steffen Rulands & Sandrine Lenglez & Guilhem Mascré & Benjamin D. Simons & Cédric Blanpain, 2017. "Defining stem cell dynamics and migration during wound healing in mouse skin epidermis," Nature Communications, Nature, vol. 8(1), pages 1-14, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14684
    DOI: 10.1038/ncomms14684
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    Cited by:

    1. Florian J. Bock & Egor Sedov & Elle Koren & Anna L. Koessinger & Catherine Cloix & Désirée Zerbst & Dimitris Athineos & Jayanthi Anand & Kirsteen J. Campbell & Karen Blyth & Yaron Fuchs & Stephen W. G, 2021. "Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Sayan Chakraborty & Divyaleka Sampath & Melissa Ong Yu Lin & Matthew Bilton & Cheng-Kuang Huang & Mui Hoon Nai & Kizito Njah & Pierre-Alexis Goy & Cheng-Chun Wang & Ernesto Guccione & Chwee-Teck Lim &, 2021. "Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Daniel Jun-Kit Hu & Jina Yun & Justin Elstrott & Heinrich Jasper, 2021. "Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Karen L. Xu & Nikolas Caprio & Hooman Fallahi & Mohammad Dehghany & Matthew D. Davidson & Lorielle Laforest & Brian C. H. Cheung & Yuqi Zhang & Mingming Wu & Vivek Shenoy & Lin Han & Robert L. Mauck &, 2024. "Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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