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Translational repression by a miniature inverted-repeat transposable element in the 3′ untranslated region

Author

Listed:
  • Jianqiang Shen

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Juhong Liu

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Kabin Xie

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University
    College of Plant Science and Technology, Huazhong Agricultural University)

  • Feng Xing

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Fang Xiong

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Jinghua Xiao

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Xianghua Li

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

  • Lizhong Xiong

    (National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University)

Abstract

Transposable elements constitute a substantial portion of eukaryotic genomes and contribute to genomic variation, function, and evolution. Miniature inverted-repeat transposable elements (MITEs), as DNA transposons, are widely distributed in plant and animal genomes. Previous studies have suggested that retrotransposons act as translational regulators; however, it remains unknown how host mRNAs are influenced by DNA transposons. Here we report a translational repression mechanism mediated by a stowaway-like MITE (sMITE) embedded in the 3′-untranslated region (3′-UTR) of Ghd2, a member of the CCT (CONSTANS [CO], CO-LIKE and TIMING OF CAB1) gene family in rice. Ghd2 regulates important agronomic traits, including grain number, plant height and heading date. Interestingly, the translational repression of Ghd2 by the sMITE mainly relies on Dicer-like 3a (OsDCL3a). Furthermore, other MITEs in the 3′-UTRs of different rice genes exhibit a similar effect on translational repression, thus suggesting that MITEs may exert a general regulatory function at the translational level.

Suggested Citation

  • Jianqiang Shen & Juhong Liu & Kabin Xie & Feng Xing & Fang Xiong & Jinghua Xiao & Xianghua Li & Lizhong Xiong, 2017. "Translational repression by a miniature inverted-repeat transposable element in the 3′ untranslated region," Nature Communications, Nature, vol. 8(1), pages 1-10, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14651
    DOI: 10.1038/ncomms14651
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    Cited by:

    1. Kang Hu & Peng Ni & Minghua Xu & You Zou & Jianye Chang & Xin Gao & Yaohang Li & Jue Ruan & Bin Hu & Jianxin Wang, 2024. "HiTE: a fast and accurate dynamic boundary adjustment approach for full-length transposable element detection and annotation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Huaijun Wang & Tiantian Ye & Zilong Guo & Yilong Yao & Haifu Tu & Pengfei Wang & Yu Zhang & Yao Wang & Xiaokai Li & Bingchen Li & Haiyan Xiong & Xuelei Lai & Lizhong Xiong, 2024. "A double-stranded RNA binding protein enhances drought resistance via protein phase separation in rice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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