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Amygdala-hippocampal dynamics during salient information processing

Author

Listed:
  • Jie Zheng

    (University of California)

  • Kristopher L. Anderson

    (Helen Wills Neuroscience Institute, University of California
    University of California)

  • Stephanie L. Leal

    (University of California)

  • Avgusta Shestyuk

    (Helen Wills Neuroscience Institute, University of California)

  • Gultekin Gulsen

    (University of California)

  • Lilit Mnatsakanyan

    (Comprehensive Epilepsy Program, University of California)

  • Sumeet Vadera

    (University of California)

  • Frank P. K. Hsu

    (University of California)

  • Michael A. Yassa

    (University of California
    Comprehensive Epilepsy Program, University of California)

  • Robert T. Knight

    (Helen Wills Neuroscience Institute, University of California
    University of California)

  • Jack J. Lin

    (Comprehensive Epilepsy Program, University of California)

Abstract

Recognizing motivationally salient information is critical to guiding behaviour. The amygdala and hippocampus are thought to support this operation, but the circuit-level mechanism of this interaction is unclear. We used direct recordings in the amygdala and hippocampus from human epilepsy patients to examine oscillatory activity during processing of fearful faces compared with neutral landscapes. We report high gamma (70–180 Hz) activation for fearful faces with earlier stimulus evoked onset in the amygdala compared with the hippocampus. Attending to fearful faces compared with neutral landscape stimuli enhances low-frequency coupling between the amygdala and the hippocampus. The interaction between the amygdala and hippocampus is largely unidirectional, with theta/alpha oscillations in the amygdala modulating hippocampal gamma activity. Granger prediction, phase slope index and phase lag analysis corroborate this directional coupling. These results demonstrate that processing emotionally salient events in humans engages an amygdala-hippocampal network, with the amygdala influencing hippocampal dynamics during fear processing.

Suggested Citation

  • Jie Zheng & Kristopher L. Anderson & Stephanie L. Leal & Avgusta Shestyuk & Gultekin Gulsen & Lilit Mnatsakanyan & Sumeet Vadera & Frank P. K. Hsu & Michael A. Yassa & Robert T. Knight & Jack J. Lin, 2017. "Amygdala-hippocampal dynamics during salient information processing," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14413
    DOI: 10.1038/ncomms14413
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    Cited by:

    1. Jay L. Gill & Julia A. Schneiders & Matthias Stangl & Zahra M. Aghajan & Mauricio Vallejo & Sonja Hiller & Uros Topalovic & Cory S. Inman & Diane Villaroman & Ausaf Bari & Avishek Adhikari & Vikram R., 2023. "A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Manuela Costa & Diego Lozano-Soldevilla & Antonio Gil-Nagel & Rafael Toledano & Carina R. Oehrn & Lukas Kunz & Mar Yebra & Costantino Mendez-Bertolo & Lennart Stieglitz & Johannes Sarnthein & Nikolai , 2022. "Aversive memory formation in humans involves an amygdala-hippocampus phase code," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Jin Li & Dan Cao & Shan Yu & Xinyu Xiao & Lukas Imbach & Lennart Stieglitz & Johannes Sarnthein & Tianzi Jiang, 2023. "Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    4. Huixin Tan & Xiaoyu Zeng & Jun Ni & Kun Liang & Cuiping Xu & Yanyang Zhang & Jiaxin Wang & Zizhou Li & Jiaxin Yang & Chunlei Han & Yuan Gao & Xinguang Yu & Shihui Han & Fangang Meng & Yina Ma, 2024. "Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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