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The molecular basis of endothelial cell plasticity

Author

Listed:
  • Elisabetta Dejana

    (Vascular Biology Unit, FIRC Institute of Molecular Oncology
    Genetics and Pathology, Uppsala University)

  • Karen K. Hirschi

    (Yale Cardiovasc. Res. Center, Genetics and Biomedical Engineering)

  • Michael Simons

    (Yale Cardiovascular Research Center, Yale University School of Medicine)

Abstract

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also undergo hematopoietic transition giving rise to multi-lineage hematopoietic stem and progenitors while others acquire mesenchymal properties necessary for heart development. In the adult, maintenance of differentiated endothelial state is an active process requiring constant signalling input. The failure to do so leads to the development of endothelial-to-mesenchymal transition that plays an important role in pathogenesis of a number of diseases. A better understanding of these phenotypic changes may lead to development of new therapeutic interventions.

Suggested Citation

  • Elisabetta Dejana & Karen K. Hirschi & Michael Simons, 2017. "The molecular basis of endothelial cell plasticity," Nature Communications, Nature, vol. 8(1), pages 1-11, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14361
    DOI: 10.1038/ncomms14361
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    Cited by:

    1. Jie Lv & Shu Meng & Qilin Gu & Rongbin Zheng & Xinlei Gao & Jun-dae Kim & Min Chen & Bo Xia & Yihan Zuo & Sen Zhu & Dongyu Zhao & Yanqiang Li & Guangyu Wang & Xin Wang & Qingshu Meng & Qi Cao & John P, 2023. "Epigenetic landscape reveals MECOM as an endothelial lineage regulator," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Fei Wang & Peiwen Ding & Xue Liang & Xiangning Ding & Camilla Blunk Brandt & Evelina Sjöstedt & Jiacheng Zhu & Saga Bolund & Lijing Zhang & Laura P. M. H. Rooij & Lihua Luo & Yanan Wei & Wandong Zhao , 2022. "Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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