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Constraints and spandrels of interareal connectomes

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  • Mikail Rubinov

    (Behavioural and Clinical Neuroscience Institute, University of Cambridge
    Janelia Research Campus, Howard Hughes Medical Institute,)

Abstract

Interareal connectomes are whole-brain wiring diagrams of white-matter pathways. Recent studies have identified modules, hubs, module hierarchies and rich clubs as structural hallmarks of these wiring diagrams. An influential current theory postulates that connectome modules are adequately explained by evolutionary pressures for wiring economy, but that the other hallmarks are not explained by such pressures and are therefore less trivial. Here, we use constraint network models to test these postulates in current gold-standard vertebrate and invertebrate interareal-connectome reconstructions. We show that empirical wiring-cost constraints inadequately explain connectome module organization, and that simultaneous module and hub constraints induce the structural byproducts of hierarchies and rich clubs. These byproducts, known as spandrels in evolutionary biology, include the structural substrate of the default-mode network. Our results imply that currently standard connectome characterizations are based on circular analyses or double dipping, and we emphasize an integrative approach to future connectome analyses for avoiding such pitfalls.

Suggested Citation

  • Mikail Rubinov, 2016. "Constraints and spandrels of interareal connectomes," Nature Communications, Nature, vol. 7(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13812
    DOI: 10.1038/ncomms13812
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    Cited by:

    1. Jessica Dafflon & Pedro F. Da Costa & František Váša & Ricardo Pio Monti & Danilo Bzdok & Peter J. Hellyer & Federico Turkheimer & Jonathan Smallwood & Emily Jones & Robert Leech, 2022. "A guided multiverse study of neuroimaging analyses," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Yuhan Chen & Shengjun Wang & Claus C Hilgetag & Changsong Zhou, 2017. "Features of spatial and functional segregation and integration of the primate connectome revealed by trade-off between wiring cost and efficiency," PLOS Computational Biology, Public Library of Science, vol. 13(9), pages 1-37, September.
    3. Pigorsch, U. & Sabek, M., 2022. "Assortative mixing in weighted directed networks," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 604(C).

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