IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v7y2016i1d10.1038_ncomms13419.html
   My bibliography  Save this article

Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease

Author

Listed:
  • Walid Mottawea

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa
    Faculty of Pharmacy, Mansoura University)

  • Cheng-Kang Chiang

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • Marcus Mühlbauer

    (Hepatology and Nutrition, University of Florida)

  • Amanda E. Starr

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • James Butcher

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • Turki Abujamel

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • Shelley A. Deeke

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • Annette Brandel

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

  • Hu Zhou

    (Ottawa Institute of Systems Biology, University of Ottawa
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

  • Shadi Shokralla

    (Biodiversity Institute of Ontario, University of Guelph)

  • Mehrdad Hajibabaei

    (Biodiversity Institute of Ontario, University of Guelph)

  • Ruth Singleton

    (Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute)

  • Eric I. Benchimol

    (Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute
    University of Ottawa
    School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa)

  • Christian Jobin

    (University of Florida)

  • David R. Mack

    (Children’s Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre and CHEO Research Institute
    University of Ottawa)

  • Daniel Figeys

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa
    University of Ottawa)

  • Alain Stintzi

    (Microbiology and Immunology, University of Ottawa
    Ottawa Institute of Systems Biology, University of Ottawa)

Abstract

Intestinal microbial dysbiosis is associated with Crohn’s disease (CD). However, the mechanisms leading to the chronic mucosal inflammation that characterizes this disease remain unclear. In this report, we use systems-level approaches to study the interactions between the gut microbiota and host in new-onset paediatric patients to evaluate causality and mechanisms of disease. We report an altered host proteome in CD patients indicative of impaired mitochondrial functions. In particular, mitochondrial proteins implicated in H2S detoxification are downregulated, while the relative abundance of H2S microbial producers is increased. Network correlation analysis reveals that Atopobium parvulum controls the central hub of H2S producers. A. parvulum induces pancolitis in colitis-susceptible interleukin-10-deficient mice and this phenotype requires the presence of the intestinal microbiota. Administrating the H2S scavenger bismuth mitigates A. parvulum-induced colitis in vivo. This study reveals that host–microbiota interactions are disturbed in CD and thus provides mechanistic insights into CD pathogenesis.

Suggested Citation

  • Walid Mottawea & Cheng-Kang Chiang & Marcus Mühlbauer & Amanda E. Starr & James Butcher & Turki Abujamel & Shelley A. Deeke & Annette Brandel & Hu Zhou & Shadi Shokralla & Mehrdad Hajibabaei & Ruth Si, 2016. "Altered intestinal microbiota–host mitochondria crosstalk in new onset Crohn’s disease," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13419
    DOI: 10.1038/ncomms13419
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms13419
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/ncomms13419?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Huimin Ye & Sabrina Borusak & Claudia Eberl & Julia Krasenbrink & Anna S. Weiss & Song-Can Chen & Buck T. Hanson & Bela Hausmann & Craig W. Herbold & Manuel Pristner & Benjamin Zwirzitz & Benedikt War, 2023. "Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Tzipi Braun & Rui Feng & Amnon Amir & Nina Levhar & Hila Shacham & Ren Mao & Rotem Hadar & Itamar Toren & Yadid Algavi & Kathleen Abu-Saad & Shuoyu Zhuo & Gilat Efroni & Alona Malik & Orit Picard & Mi, 2024. "Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Yi Liu & Yun Yang & Wendong Chen & Feng Shen & Linhai Xie & Yingying Zhang & Yuanjun Zhai & Fuchu He & Yunping Zhu & Cheng Chang, 2023. "DeepRTAlign: toward accurate retention time alignment for large cohort mass spectrometry data analysis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13419. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.