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Theranostic barcoded nanoparticles for personalized cancer medicine

Author

Listed:
  • Zvi Yaari

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Dana da Silva

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Assaf Zinger

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Evgeniya Goldman

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Ashima Kajal

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Rafi Tshuva

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Efrat Barak

    (Infrastructure Unit, Life Science and Engineering Center, Technion—Israel Institute of Technology)

  • Nitsan Dahan

    (Infrastructure Unit, Life Science and Engineering Center, Technion—Israel Institute of Technology)

  • Dov Hershkovitz

    (Clinical Pathology Unit, Rambam Medical Center)

  • Mor Goldfeder

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Janna Shainsky Roitman

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

  • Avi Schroeder

    (Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Technion—Israel Institute of Technology)

Abstract

Personalized medicine promises to revolutionize cancer therapy by matching the most effective treatment to the individual patient. Using a nanoparticle-based system, we predict the therapeutic potency of anticancer medicines in a personalized manner. We carry out the diagnostic stage through a multidrug screen performed inside the tumour, extracting drug activity information with single cell sensitivity. By using 100 nm liposomes, loaded with various cancer drugs and corresponding synthetic DNA barcodes, we find a correlation between the cell viability and the drug it was exposed to, according to the matching barcodes. Based on this screen, we devise a treatment protocol for mice bearing triple-negative breast-cancer tumours, and its results confirm the diagnostic prediction. We show that the use of nanotechnology in cancer care is effective for generating personalized treatment protocols.

Suggested Citation

  • Zvi Yaari & Dana da Silva & Assaf Zinger & Evgeniya Goldman & Ashima Kajal & Rafi Tshuva & Efrat Barak & Nitsan Dahan & Dov Hershkovitz & Mor Goldfeder & Janna Shainsky Roitman & Avi Schroeder, 2016. "Theranostic barcoded nanoparticles for personalized cancer medicine," Nature Communications, Nature, vol. 7(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13325
    DOI: 10.1038/ncomms13325
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    Cited by:

    1. Jiaye Liu & Yang Wang & Chunyang Mu & Meng Li & Kewei Li & Shan Li & Wenshuang Wu & Lingyao Du & Xiaoyun Zhang & Chuan Li & Wei Peng & Junyi Shen & Yang Liu & Dujiang Yang & Kaixiang Zhang & Qingyang , 2022. "Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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