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Vasculogenic mimicry in small cell lung cancer

Author

Listed:
  • Stuart C. Williamson

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Robert L. Metcalf

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Francesca Trapani

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Sumitra Mohan

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Jenny Antonello

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Benjamin Abbott

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Hui Sun Leong

    (Computational Biology Support Team, Cancer Research UK Manchester Institute)

  • Christopher P. E. Chester

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Nicole Simms

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Radoslaw Polanski

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Daisuke Nonaka

    (The Christie NHS Foundation Trust)

  • Lynsey Priest

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Alberto Fusi

    (The Christie NHS Foundation Trust)

  • Fredrika Carlsson

    (University of Southern California Dornsife)

  • Anders Carlsson

    (University of Southern California Dornsife)

  • Mary J. C. Hendrix

    (Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine)

  • Richard E. B. Seftor

    (Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine)

  • Elisabeth A. Seftor

    (Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine)

  • Dominic G. Rothwell

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Andrew Hughes

    (The Institute of Cancer Sciences, University of Manchester)

  • James Hicks

    (University of Southern California Dornsife)

  • Crispin Miller

    (RNA Biology Group, Cancer Research UK Manchester Institute)

  • Peter Kuhn

    (University of Southern California Dornsife)

  • Ged Brady

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Kathryn L. Simpson

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute)

  • Fiona H. Blackhall

    (The Christie NHS Foundation Trust
    The Institute of Cancer Sciences, University of Manchester
    Cancer Research UK, Lung Cancer Centre of Excellence)

  • Caroline Dive

    (Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
    Cancer Research UK, Lung Cancer Centre of Excellence)

Abstract

Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form ‘endothelial-like’ vessels. Single-cell genomic analysis reveals characteristic SCLC genomic changes in both VE-cadherin-positive and -negative CTCs. Higher levels of VM are associated with worse overall survival in 41 limited-stage patients’ biopsies (P

Suggested Citation

  • Stuart C. Williamson & Robert L. Metcalf & Francesca Trapani & Sumitra Mohan & Jenny Antonello & Benjamin Abbott & Hui Sun Leong & Christopher P. E. Chester & Nicole Simms & Radoslaw Polanski & Daisuk, 2016. "Vasculogenic mimicry in small cell lung cancer," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13322
    DOI: 10.1038/ncomms13322
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    Cited by:

    1. Maximilian W. Schenk & Sam Humphrey & A. S. Md Mukarram Hossain & Mitchell Revill & Sarah Pearsall & Alice Lallo & Stewart Brown & Samuel Bratt & Melanie Galvin & Tine Descamps & Cong Zhou & Simon P. , 2021. "Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    2. Yan Ting Shue & Alexandros P. Drainas & Nancy Yanzhe Li & Sarah M. Pearsall & Derrick Morgan & Nasa Sinnott-Armstrong & Susan Q. Hipkins & Garry L. Coles & Jing Shan Lim & Anthony E. Oro & Kathryn L. , 2022. "A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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