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A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication

Author

Listed:
  • Daniela Carnevale

    (IRCCS Neuromed
    ‘Sapienza’ University of Rome)

  • Marialuisa Perrotta

    (IRCCS Neuromed)

  • Fabio Pallante

    (IRCCS Neuromed)

  • Valentina Fardella

    (IRCCS Neuromed)

  • Roberta Iacobucci

    (IRCCS Neuromed)

  • Stefania Fardella

    (IRCCS Neuromed)

  • Lorenzo Carnevale

    (IRCCS Neuromed)

  • Raimondo Carnevale

    (IRCCS Neuromed)

  • Massimiliano De Lucia

    (IRCCS Neuromed)

  • Giuseppe Cifelli

    (IRCCS Neuromed)

  • Giuseppe Lembo

    (IRCCS Neuromed
    ‘Sapienza’ University of Rome)

Abstract

The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connection are unknown. Here, we show that hypertensive challenges activate splenic sympathetic nerve discharge to prime immune response. More specifically, a vagus-splenic nerve drive, mediated by nicotinic cholinergic receptors, links the brain and spleen. The sympathetic discharge induced by hypertensive stimuli was absent in both coeliac vagotomized mice and in mice lacking α7nAChR, a receptor typically expressed by peripheral ganglionic neurons. This cholinergic-sympathetic pathway is necessary for T cell activation and egression on hypertensive challenges. In addition, we show that selectively thermoablating the splenic nerve prevents T cell egression and protects against hypertension. This novel experimental procedure for selective splenic denervation suggests new clinical strategies for resistant hypertension.

Suggested Citation

  • Daniela Carnevale & Marialuisa Perrotta & Fabio Pallante & Valentina Fardella & Roberta Iacobucci & Stefania Fardella & Lorenzo Carnevale & Raimondo Carnevale & Massimiliano De Lucia & Giuseppe Cifell, 2016. "A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication," Nature Communications, Nature, vol. 7(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13035
    DOI: 10.1038/ncomms13035
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    Cited by:

    1. Lorenzo Carnevale & Marialuisa Perrotta & Giuseppe Lembo, 2018. "Microneurography of Peripheral Nerves in Mice: An Old Approach Applied to the Novel Concept of Neural Modulation of Immune Organs in Cardiovascular Diseases," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 2(5), pages 2843-2845, February.

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