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Organization of olfactory centres in the malaria mosquito Anopheles gambiae

Author

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  • Olena Riabinina

    (Center for Sensory Biology, Johns Hopkins University School of Medicine
    Present address: MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK)

  • Darya Task

    (Center for Sensory Biology, Johns Hopkins University School of Medicine)

  • Elizabeth Marr

    (Center for Sensory Biology, Johns Hopkins University School of Medicine)

  • Chun-Chieh Lin

    (Center for Sensory Biology, Johns Hopkins University School of Medicine)

  • Robert Alford

    (University of Maryland College Park)

  • David A. O'Brochta

    (University of Maryland College Park)

  • Christopher J. Potter

    (Center for Sensory Biology, Johns Hopkins University School of Medicine)

Abstract

Mosquitoes are vectors for multiple infectious human diseases and use a variety of sensory cues (olfactory, temperature, humidity and visual) to locate a human host. A comprehensive understanding of the circuitry underlying sensory signalling in the mosquito brain is lacking. Here we used the Q-system of binary gene expression to develop transgenic lines of Anopheles gambiae in which olfactory receptor neurons expressing the odorant receptor co-receptor (Orco) gene are labelled with GFP. These neurons project from the antennae and maxillary palps to the antennal lobe (AL) and from the labella on the proboscis to the suboesophageal zone (SEZ), suggesting integration of olfactory and gustatory signals occurs in this brain region. We present detailed anatomical maps of olfactory innervations in the AL and the SEZ, identifying glomeruli that may respond to human body odours or carbon dioxide. Our results pave the way for anatomical and functional neurogenetic studies of sensory processing in mosquitoes.

Suggested Citation

  • Olena Riabinina & Darya Task & Elizabeth Marr & Chun-Chieh Lin & Robert Alford & David A. O'Brochta & Christopher J. Potter, 2016. "Organization of olfactory centres in the malaria mosquito Anopheles gambiae," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13010
    DOI: 10.1038/ncomms13010
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    Cited by:

    1. Pranjul Singh & Shefali Goyal & Smith Gupta & Sanket Garg & Abhinav Tiwari & Varad Rajput & Alexander Shakeel Bates & Arjit Kant Gupta & Nitin Gupta, 2023. "Combinatorial encoding of odors in the mosquito antennal lobe," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Tales V. Pascini & Yeong Je Jeong & Wei Huang & Zarna R. Pala & Juliana M. Sá & Michael B. Wells & Christopher Kizito & Brendan Sweeney & Thiago L. Alves e Silva & Deborah J. Andrew & Marcelo Jacobs-­, 2022. "Transgenic Anopheles mosquitoes expressing human PAI-1 impair malaria transmission," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Rosario Vicidomini & Saumitra Dey Choudhury & Tae Hee Han & Tho Huu Nguyen & Peter Nguyen & Felipe Opazo & Mihaela Serpe, 2024. "Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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