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N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi

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  • Chang Su

    (University of California)

  • Yang Lu

    (University of California)

  • Haoping Liu

    (University of California)

Abstract

N-acetylglucosamine (GlcNAc) exists ubiquitously as a component of the surface on a wide range of cells, from bacteria to humans. Many fungi are able to utilize environmental GlcNAc to support growth and induce cellular development, a property important for their survival in various host niches. However, how the GlcNAc signal is sensed and subsequently transduced is largely unknown. Here, we identify a gene that is essential for GlcNAc signalling (NGS1) in Candida albicans, a commensal and pathogenic yeast of humans. Ngs1 can bind GlcNAc through the N-terminal β-N-acetylglucosaminidase homology domain. This binding activates N-acetyltransferase activity in the C-terminal GCN5-related N-acetyltransferase domain, which is required for GlcNAc-induced promoter histone acetylation and transcription. Ngs1 is targeted to the promoters of GlcNAc-inducible genes constitutively by the transcription factor Rep1. Ngs1 is conserved in diverse fungi that have GlcNAc catabolic genes. Thus, fungi use Ngs1 as a GlcNAc-sensor and transducer for GlcNAc-induced transcription.

Suggested Citation

  • Chang Su & Yang Lu & Haoping Liu, 2016. "N-acetylglucosamine sensing by a GCN5-related N-acetyltransferase induces transcription via chromatin histone acetylation in fungi," Nature Communications, Nature, vol. 7(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12916
    DOI: 10.1038/ncomms12916
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    Cited by:

    1. Tingting Zhou & Norma V. Solis & Michaela Marshall & Qing Yao & Rachel Garleb & Mengli Yang & Eric Pearlman & Scott G. Filler & Haoping Liu, 2024. "Hyphal Als proteins act as CR3 ligands to promote immune responses against Candida albicans," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Dandan Yang & Mao Zhang & Chang Su & Bin Dong & Yang Lu, 2023. "Candida albicans exploits N-acetylglucosamine as a gut signal to establish the balance between commensalism and pathogenesis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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