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Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility

Author

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  • Ian Linsmeier

    (Yale University
    Systems Biology Institute, Yale University)

  • Shiladitya Banerjee

    (James Franck Institute, University of Chicago
    Present addresses: Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, Gower Street, London WC1E 6BT, UK)

  • Patrick W. Oakes

    (James Franck Institute, University of Chicago
    Present addresses: Department of Physics & Astronomy, University of Rochester, Rochester, New York 14627, USA)

  • Wonyeong Jung

    (School of Mechanical Engineering, 585 Purdue Mall, Purdue University)

  • Taeyoon Kim

    (Weldon School of Biomedical Engineering)

  • Michael P. Murrell

    (Yale University
    Systems Biology Institute, Yale University)

Abstract

While the molecular interactions between individual myosin motors and F-actin are well established, the relationship between F-actin organization and actomyosin forces remains poorly understood. Here we explore the accumulation of myosin-induced stresses within a two-dimensional biomimetic model of the disordered actomyosin cytoskeleton, where myosin activity is controlled spatiotemporally using light. By controlling the geometry and the duration of myosin activation, we show that contraction of disordered actin networks is highly cooperative, telescopic with the activation size, and capable of generating non-uniform patterns of mechanical stress. We quantitatively reproduce these collective biomimetic properties using an isotropic active gel model of the actomyosin cytoskeleton, and explore the physical origins of telescopic contractility in disordered networks using agent-based simulations.

Suggested Citation

  • Ian Linsmeier & Shiladitya Banerjee & Patrick W. Oakes & Wonyeong Jung & Taeyoon Kim & Michael P. Murrell, 2016. "Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility," Nature Communications, Nature, vol. 7(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12615
    DOI: 10.1038/ncomms12615
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    Cited by:

    1. Bibi Najma & Minu Varghese & Lev Tsidilkovski & Linnea Lemma & Aparna Baskaran & Guillaume Duclos, 2022. "Competing instabilities reveal how to rationally design and control active crosslinked gels," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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