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Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

Author

Listed:
  • Hiroaki Konishi

    (Asahikawa Medical University)

  • Mikihiro Fujiya

    (Asahikawa Medical University)

  • Hiroki Tanaka

    (Asahikawa Medical University)

  • Nobuhiro Ueno

    (Asahikawa Medical University)

  • Kentaro Moriichi

    (Asahikawa Medical University)

  • Junpei Sasajima

    (Asahikawa Medical University)

  • Katsuya Ikuta

    (Asahikawa Medical University)

  • Hiroaki Akutsu

    (Center for Advanced Research and Education, Asahikawa Medical University)

  • Hiroki Tanabe

    (International University of Health and Welfare Hospital)

  • Yutaka Kohgo

    (International University of Health and Welfare Hospital)

Abstract

Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved have not yet been identified. Here, we show that the culture supernatant of Lactobacillus casei ATCC334 has a strong tumour-suppressive effect on colon cancer cells. Using mass spectrometry, we identify ferrichrome as a tumour-suppressive molecule produced by L. casei ATCC334. The tumour-suppressive effect of ferrichrome is greater than that of cisplatin and 5-fluorouracil, and ferrichrome has less of an effect on non-cancerous intestinal cells than either of those agents. A transcriptome analysis reveals that ferrichrome treatment induces apoptosis, which is mediated by the activation of c-jun N-terminal kinase (JNK). Western blotting indicates that the induction of apoptosis by ferrichrome is reduced by the inhibition of the JNK signalling pathway. This we demonstrate that probiotic-derived ferrichrome exerts a tumour-suppressive effect via the JNK signalling pathway.

Suggested Citation

  • Hiroaki Konishi & Mikihiro Fujiya & Hiroki Tanaka & Nobuhiro Ueno & Kentaro Moriichi & Junpei Sasajima & Katsuya Ikuta & Hiroaki Akutsu & Hiroki Tanabe & Yutaka Kohgo, 2016. "Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12365
    DOI: 10.1038/ncomms12365
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    Cited by:

    1. Jiezhou Pan & Guidong Gong & Qin Wang & Jiaojiao Shang & Yunxiang He & Chelsea Catania & Dan Birnbaum & Yifei Li & Zhijun Jia & Yaoyao Zhang & Neel S. Joshi & Junling Guo, 2022. "A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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