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Intrinsic limits to gene regulation by global crosstalk

Author

Listed:
  • Tamar Friedlander

    (Institute of Science and Technology Austria)

  • Roshan Prizak

    (Institute of Science and Technology Austria)

  • Călin C. Guet

    (Institute of Science and Technology Austria)

  • Nicholas H. Barton

    (Institute of Science and Technology Austria)

  • Gašper Tkačik

    (Institute of Science and Technology Austria)

Abstract

Gene regulation relies on the specificity of transcription factor (TF)–DNA interactions. Limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF–DNA interactions or remains erroneously inactive. As each TF can have numerous interactions with noncognate cis-regulatory elements, crosstalk is inherently a global problem, yet has previously not been studied as such. We construct a theoretical framework to analyse the effects of global crosstalk on gene regulation. We find that crosstalk presents a significant challenge for organisms with low-specificity TFs, such as metazoans. Crosstalk is not easily mitigated by known regulatory schemes acting at equilibrium, including variants of cooperativity and combinatorial regulation. Our results suggest that crosstalk imposes a previously unexplored global constraint on the functioning and evolution of regulatory networks, which is qualitatively distinct from the known constraints that act at the level of individual gene regulatory elements.

Suggested Citation

  • Tamar Friedlander & Roshan Prizak & Călin C. Guet & Nicholas H. Barton & Gašper Tkačik, 2016. "Intrinsic limits to gene regulation by global crosstalk," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12307
    DOI: 10.1038/ncomms12307
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    Cited by:

    1. Keren Erez & Amit Jangid & Ohad Noy Feldheim & Tamar Friedlander, 2024. "The role of promiscuous molecular recognition in the evolution of RNase-based self-incompatibility in plants," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Rok Grah & Tamar Friedlander, 2020. "The relation between crosstalk and gene regulation form revisited," PLOS Computational Biology, Public Library of Science, vol. 16(2), pages 1-24, February.

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