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Simultaneous optical and electrical in vivo analysis of the enteric nervous system

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Listed:
  • Nikolai Rakhilin

    (School of Electrical and Computer Engineering, Cornell University)

  • Bradley Barth

    (Cornell University
    Duke University)

  • Jiahn Choi

    (Cornell University)

  • Nini L. Muñoz

    (School of Electrical and Computer Engineering, Cornell University)

  • Subhash Kulkarni

    (Center for Neurogastroenterology, Johns Hopkins University)

  • Jason S. Jones

    (Cornell University)

  • David M. Small

    (Cornell University)

  • Yu-Ting Cheng

    (Cornell University)

  • Yingqiu Cao

    (School of Electrical and Computer Engineering, Cornell University)

  • Colleen LaVinka

    (Center for Sensory Biology, Johns Hopkins University School of Medicine)

  • Edwin Kan

    (School of Electrical and Computer Engineering, Cornell University)

  • Xinzhong Dong

    (Center for Sensory Biology, Johns Hopkins University School of Medicine
    Howard Hughes Medical Institute, Chevy Chase)

  • Michael Spencer

    (School of Electrical and Computer Engineering, Cornell University)

  • Pankaj Pasricha

    (Center for Neurogastroenterology, Johns Hopkins University)

  • Nozomi Nishimura

    (Cornell University)

  • Xiling Shen

    (School of Electrical and Computer Engineering, Cornell University
    Cornell University
    Duke University)

Abstract

The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.

Suggested Citation

  • Nikolai Rakhilin & Bradley Barth & Jiahn Choi & Nini L. Muñoz & Subhash Kulkarni & Jason S. Jones & David M. Small & Yu-Ting Cheng & Yingqiu Cao & Colleen LaVinka & Edwin Kan & Xinzhong Dong & Michael, 2016. "Simultaneous optical and electrical in vivo analysis of the enteric nervous system," Nature Communications, Nature, vol. 7(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11800
    DOI: 10.1038/ncomms11800
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    Cited by:

    1. Longjie Jiang & Jie Yang & Xiujuan Gao & Jiangfeng Huang & Qian Liu & Ling Fu, 2024. "In vivo imaging of vagal-induced myenteric plexus responses in gastrointestinal tract with an optical window," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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