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aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis

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Listed:
  • Renuka Raman

    (Tata Institute of Fundamental Research)

  • Indraneel Damle

    (Tata Institute of Fundamental Research)

  • Rahul Rote

    (Tata Institute of Fundamental Research
    Present address: McGill University, Montreal, Quebec, H3A 1B1 Canada)

  • Shamik Banerjee

    (Tata Institute of Fundamental Research
    SASTRA University, Tirumalaisamudram)

  • Chaitanya Dingare

    (Tata Institute of Fundamental Research
    Present address: Albert-Ludwig-University of Freiburg, Freiburg, Germany)

  • Mahendra Sonawane

    (Tata Institute of Fundamental Research)

Abstract

Epithelial cells exhibit apical membrane protrusions, which confer specific functions to epithelial tissues. Microridges are short actin protrusions that are laterally long and form a maze-like pattern in the apical domain. They are widely found on vertebrate squamous epithelia including epidermis and have functions in mucous retention, membrane storage and abrasion resistance. It is largely unknown how the formation of these laterally long actin projections is regulated. Here, we show that antagonistic interactions between aPKC and Lgl–regulators of apical and basolateral domain identity, respectively,–control the length of microridges in the zebrafish periderm, the outermost layer of the epidermis. aPKC regulates the levels of Lgl and the active form of non-muscle myosinII at the apical cortex to prevent actin polymerization-dependent precocious fusion and elongation of microridges. Our data unravels the functional significance of exclusion of Lgl from the apical domain in epithelial cells.

Suggested Citation

  • Renuka Raman & Indraneel Damle & Rahul Rote & Shamik Banerjee & Chaitanya Dingare & Mahendra Sonawane, 2016. "aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis," Nature Communications, Nature, vol. 7(1), pages 1-16, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11643
    DOI: 10.1038/ncomms11643
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    Cited by:

    1. Takayuki Yasunaga & Johannes Wiegel & Max D. Bergen & Martin Helmstädter & Daniel Epting & Andrea Paolini & Özgün Çiçek & Gerald Radziwill & Christina Engel & Thomas Brox & Olaf Ronneberger & Peter Wa, 2022. "Microridge-like structures anchor motile cilia," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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