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Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

Author

Listed:
  • Hiromu Monai

    (RIKEN Brain Science Institute)

  • Masamichi Ohkura

    (Brain Science Institute, Saitama University)

  • Mika Tanaka

    (RIKEN Brain Science Institute)

  • Yuki Oe

    (RIKEN Brain Science Institute)

  • Ayumu Konno

    (Gunma University Graduate School of Medicine)

  • Hirokazu Hirai

    (Gunma University Graduate School of Medicine)

  • Katsuhiko Mikoshiba

    (RIKEN Brain Science Institute)

  • Shigeyoshi Itohara

    (RIKEN Brain Science Institute)

  • Junichi Nakai

    (Brain Science Institute, Saitama University)

  • Youichi Iwai

    (RIKEN Brain Science Institute)

  • Hajime Hirase

    (RIKEN Brain Science Institute
    Brain Science Institute, Saitama University)

Abstract

Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca2+ surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca2+ surges are absent. Together, we propose that tDCS changes the metaplasticity of the cortex through astrocytic Ca2+/IP3 signalling.

Suggested Citation

  • Hiromu Monai & Masamichi Ohkura & Mika Tanaka & Yuki Oe & Ayumu Konno & Hirokazu Hirai & Katsuhiko Mikoshiba & Shigeyoshi Itohara & Junichi Nakai & Youichi Iwai & Hajime Hirase, 2016. "Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain," Nature Communications, Nature, vol. 7(1), pages 1-10, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11100
    DOI: 10.1038/ncomms11100
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    Cited by:

    1. Ikuko Takeda & Kohei Yoshihara & Dennis L. Cheung & Tomoko Kobayashi & Masakazu Agetsuma & Makoto Tsuda & Kei Eto & Schuichi Koizumi & Hiroaki Wake & Andrew J. Moorhouse & Junichi Nabekura, 2022. "Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Annamaria Lia & Gabriele Sansevero & Angela Chiavegato & Miriana Sbrissa & Diana Pendin & Letizia Mariotti & Tullio Pozzan & Nicoletta Berardi & Giorgio Carmignoto & Cristina Fasolato & Micaela Zonta, 2023. "Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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