IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37240-2.html
   My bibliography  Save this article

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease

Author

Listed:
  • Annamaria Lia

    (National Research Council (CNR)
    University of Padua)

  • Gabriele Sansevero

    (National Research Council (CNR)
    University of Florence)

  • Angela Chiavegato

    (University of Padua)

  • Miriana Sbrissa

    (University of Padua)

  • Diana Pendin

    (National Research Council (CNR)
    University of Padua)

  • Letizia Mariotti

    (National Research Council (CNR)
    University of Padua)

  • Tullio Pozzan

    (National Research Council (CNR)
    University of Padua
    Foundation for Advanced Biomedical Research)

  • Nicoletta Berardi

    (National Research Council (CNR)
    University of Florence)

  • Giorgio Carmignoto

    (National Research Council (CNR)
    University of Padua)

  • Cristina Fasolato

    (University of Padua)

  • Micaela Zonta

    (National Research Council (CNR)
    University of Padua)

Abstract

Calcium dynamics in astrocytes represent a fundamental signal that through gliotransmitter release regulates synaptic plasticity and behaviour. Here we present a longitudinal study in the PS2APP mouse model of Alzheimer’s disease (AD) linking astrocyte Ca2+ hypoactivity to memory loss. At the onset of plaque deposition, somatosensory cortical astrocytes of AD female mice exhibit a drastic reduction of Ca2+ signaling, closely associated with decreased endoplasmic reticulum Ca2+ concentration and reduced expression of the Ca2+ sensor STIM1. In parallel, astrocyte-dependent long-term synaptic plasticity declines in the somatosensory circuitry, anticipating specific tactile memory loss. Notably, we show that both astrocyte Ca2+ signaling and long-term synaptic plasticity are fully recovered by selective STIM1 overexpression in astrocytes. Our data unveil astrocyte Ca2+ hypoactivity in neocortical astrocytes as a functional hallmark of early AD stages and indicate astrocytic STIM1 as a target to rescue memory deficits.

Suggested Citation

  • Annamaria Lia & Gabriele Sansevero & Angela Chiavegato & Miriana Sbrissa & Diana Pendin & Letizia Mariotti & Tullio Pozzan & Nicoletta Berardi & Giorgio Carmignoto & Cristina Fasolato & Micaela Zonta, 2023. "Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37240-2
    DOI: 10.1038/s41467-023-37240-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37240-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37240-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Letizia Mariotti & Gabriele Losi & Annamaria Lia & Marcello Melone & Angela Chiavegato & Marta Gómez-Gonzalo & Michele Sessolo & Serena Bovetti & Angelo Forli & Micaela Zonta & Linda Maria Requie & Ia, 2018. "Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Hiromu Monai & Masamichi Ohkura & Mika Tanaka & Yuki Oe & Ayumu Konno & Hirokazu Hirai & Katsuhiko Mikoshiba & Shigeyoshi Itohara & Junichi Nakai & Youichi Iwai & Hajime Hirase, 2016. "Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain," Nature Communications, Nature, vol. 7(1), pages 1-10, September.
    3. Andrea Delekate & Martina Füchtemeier & Toni Schumacher & Cordula Ulbrich & Marco Foddis & Gabor C. Petzold, 2014. "Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yung-Tian A. Gau & Eric T. Hsu & Richard J. Cha & Rebecca W. Pak & Loren L. Looger & Jin U. Kang & Dwight E. Bergles, 2024. "Multicore fiber optic imaging reveals that astrocyte calcium activity in the mouse cerebral cortex is modulated by internal motivational state," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Ikuko Takeda & Kohei Yoshihara & Dennis L. Cheung & Tomoko Kobayashi & Masakazu Agetsuma & Makoto Tsuda & Kei Eto & Schuichi Koizumi & Hiroaki Wake & Andrew J. Moorhouse & Junichi Nabekura, 2022. "Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Michaela M. Novakovic & Kirill S. Korshunov & Rogan A. Grant & Megan E. Martin & Hiam A. Valencia & G. R. Scott Budinger & Jelena Radulovic & Murali Prakriya, 2023. "Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Eiji Shigetomi & Hideaki Suzuki & Yukiho J. Hirayama & Fumikazu Sano & Yuki Nagai & Kohei Yoshihara & Keisuke Koga & Toru Tateoka & Hideyuki Yoshioka & Youichi Shinozaki & Hiroyuki Kinouchi & Kenji F., 2024. "Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37240-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.