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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Author

Listed:
  • Minako Imamura

    (Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences)

  • Atsushi Takahashi

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    Laboratory for Omics Informatics, Omics Research Center, National Cerebral And Cardiovascular Center)

  • Toshimasa Yamauchi

    (Graduate School of Medicine, University of Tokyo)

  • Kazuo Hara

    (Graduate School of Medicine, University of Tokyo
    Metabolism and Rheumatology, Tokyo Medical University)

  • Kazuki Yasuda

    (Diabetes Research Center, Research Institute, National Center for Global Health and Medicine)

  • Niels Grarup

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Wei Zhao

    (University of Pennsylvania)

  • Xu Wang

    (Saw Swee Hock School of Public Health, National University of Singapore)

  • Alicia Huerta-Chagoya

    (Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Cheng Hu

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Sanghoon Moon

    (Center for Genome Science, National Institute of Health)

  • Jirong Long

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Soo Heon Kwak

    (Seoul National University Hospital)

  • Asif Rasheed

    (Center for Non-Communicable Diseases)

  • Richa Saxena

    (Center for Human Genetic Research, Massachusetts General Hospital)

  • Ronald C. W. Ma

    (The Chinese University of Hong Kong
    Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong)

  • Yukinori Okada

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University)

  • Minoru Iwata

    (University of Toyama
    Health Administration Center, University of Toyama)

  • Jun Hosoe

    (Graduate School of Medicine, University of Tokyo)

  • Nobuhiro Shojima

    (Graduate School of Medicine, University of Tokyo)

  • Minaka Iwasaki

    (Graduate School of Medicine, University of Tokyo)

  • Hayato Fujita

    (Graduate School of Medicine, University of Tokyo)

  • Ken Suzuki

    (Graduate School of Medicine, University of Tokyo)

  • John Danesh

    (University of Cambridge
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus Hinxton
    NIHR Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge)

  • Torben Jørgensen

    (Research Centre for Prevention and Health, Capital Region of Denmark
    Faculty of Health and Medical Sciences, University of Copenhagen
    Faculty of Medicine, University of Aalborg)

  • Marit E. Jørgensen

    (Steno Diabetes Center)

  • Daniel R. Witte

    (Aarhus University
    Danish Diabetes Academy)

  • Ivan Brandslund

    (Lillebaelt Hospital
    Institute of Regional Health Research, University of Southern Denmark)

  • Cramer Christensen

    (Lillebaelt Hospital)

  • Torben Hansen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Josep M. Mercader

    (Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
    Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center
    Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital)

  • Jason Flannick

    (Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
    Harvard Medical School)

  • Hortensia Moreno-Macías

    (Universidad Autónomas Metropolitana)

  • Noël P. Burtt

    (Program in Medical and Population Genetics, Broad Institute of Harvard and MIT)

  • Rong Zhang

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Young Jin Kim

    (Center for Genome Science, National Institute of Health)

  • Wei Zheng

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Jai Rup Singh

    (Central University of Punjab)

  • Claudia H. T. Tam

    (The Chinese University of Hong Kong)

  • Hiroshi Hirose

    (Health Center, Keio University)

  • Hiroshi Maegawa

    (Shiga University of Medical Science)

  • Chikako Ito

    (Grand Tower Medical Court Life Care Clinic)

  • Kohei Kaku

    (Kawasaki Medical School)

  • Hirotaka Watada

    (Juntendo University Graduate School of Medicine
    Sportology Center, Juntendo University Graduate School of Medicine)

  • Yasushi Tanaka

    (St Marianna University School of Medicine)

  • Kazuyuki Tobe

    (University of Toyama)

  • Ryuzo Kawamori

    (Sportology Center, Juntendo University Graduate School of Medicine)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Yoon Shin Cho

    (Hallym University)

  • Juliana C. N. Chan

    (The Chinese University of Hong Kong
    Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong)

  • Dharambir Sanghera

    (University of Oklahoma Health Sciences Center
    University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, n)

  • Philippe Frossard

    (Center for Non-Communicable Diseases)

  • Kyong Soo Park

    (Seoul National University Hospital
    Seoul National University College of Medicine
    Graduate School of Convergence Science and Technology, Seoul National University)

  • Xiao-Ou Shu

    (Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine)

  • Bong-Jo Kim

    (Center for Genome Science, National Institute of Health)

  • Jose C. Florez

    (Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
    Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital
    Harvard Medical School)

  • Teresa Tusié-Luna

    (Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán)

  • Weiping Jia

    (Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • E Shyong Tai

    (Saw Swee Hock School of Public Health, National University of Singapore
    Yong Loo Lin School of Medicine, National University of Singapore
    Duke-National University of Singapore Graduate School)

  • Oluf Pedersen

    (The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Danish Saleheen

    (University of Pennsylvania
    Center for Non-Communicable Diseases)

  • Shiro Maeda

    (Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences
    Graduate School of Medicine, University of the Ryukyus
    University of the Ryukyus Hospital)

  • Takashi Kadowaki

    (Graduate School of Medicine, University of Tokyo)

Abstract

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P

Suggested Citation

  • Minako Imamura & Atsushi Takahashi & Toshimasa Yamauchi & Kazuo Hara & Kazuki Yasuda & Niels Grarup & Wei Zhao & Xu Wang & Alicia Huerta-Chagoya & Cheng Hu & Sanghoon Moon & Jirong Long & Soo Heon Kwa, 2016. "Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10531
    DOI: 10.1038/ncomms10531
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    Cited by:

    1. Duc-Hau Le, 2021. "A network-based method for predicting disease-associated enhancers," PLOS ONE, Public Library of Science, vol. 16(12), pages 1-20, December.

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