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Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

Author

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  • Daniel C. Berry

    (The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center)

  • Yuwei Jiang

    (The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center)

  • Jonathan M. Graff

    (The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center
    The University of Texas Southwestern Medical Center)

Abstract

Cold temperatures induce formation of beige adipocytes, which convert glucose and fatty acids to heat, and may increase energy expenditure, reduce adiposity and lower blood glucose. This therapeutic potential is unrealized, hindered by a dearth of genetic tools to fate map, track and manipulate beige progenitors and ‘beiging’. Here we examined 12 Cre/inducible Cre mouse strains that mark adipocyte, muscle and mural lineages, three proposed beige origins. Among these mouse strains, only those that marked perivascular mural cells tracked the cold-induced beige lineage. Two SMA-based strains, SMA-CreERT2 and SMA-rtTA, fate mapped into the majority of cold-induced beige adipocytes and SMA-marked progenitors appeared essential for beiging. Disruption of the potential of the SMA-tracked progenitors to form beige adipocytes was accompanied by an inability to maintain body temperature and by hyperglycaemia. Thus, SMA-engineered mice may be useful to track and manipulate beige progenitors, beige adipocyte formation and function.

Suggested Citation

  • Daniel C. Berry & Yuwei Jiang & Jonathan M. Graff, 2016. "Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function," Nature Communications, Nature, vol. 7(1), pages 1-17, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10184
    DOI: 10.1038/ncomms10184
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    Cited by:

    1. Benjamin M. Steiner & Abigail M. Benvie & Derek Lee & Yuwei Jiang & Daniel C. Berry, 2024. "Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Abigail M. Benvie & Derek Lee & Benjamin M. Steiner & Siwen Xue & Yuwei Jiang & Daniel C. Berry, 2023. "Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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