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Saccadic modulation of stimulus processing in primary visual cortex

Author

Listed:
  • James M. McFarland

    (University of Maryland)

  • Adrian G. Bondy

    (Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health
    Brown-NIH Neuroscience Graduate Partnership Program, Brown University)

  • Richard C. Saunders

    (Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health)

  • Bruce G. Cumming

    (Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health)

  • Daniel A. Butts

    (University of Maryland)

Abstract

Saccadic eye movements play a central role in primate vision. Yet, relatively little is known about their effects on the neural processing of visual inputs. Here we examine this question in primary visual cortex (V1) using receptive-field-based models, combined with an experimental design that leaves the retinal stimulus unaffected by saccades. This approach allows us to analyse V1 stimulus processing during saccades with unprecedented detail, revealing robust perisaccadic modulation. In particular, saccades produce biphasic firing rate changes that are composed of divisive gain suppression followed by an additive rate increase. Microsaccades produce similar, though smaller, modulations. We furthermore demonstrate that this modulation is likely inherited from the LGN, and is driven largely by extra-retinal signals. These results establish a foundation for integrating saccades into existing models of visual cortical stimulus processing, and highlight the importance of studying visual neuron function in the context of eye movements.

Suggested Citation

  • James M. McFarland & Adrian G. Bondy & Richard C. Saunders & Bruce G. Cumming & Daniel A. Butts, 2015. "Saccadic modulation of stimulus processing in primary visual cortex," Nature Communications, Nature, vol. 6(1), pages 1-14, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9110
    DOI: 10.1038/ncomms9110
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    Cited by:

    1. Zhetuo Zhao & Ehud Ahissar & Jonathan D. Victor & Michele Rucci, 2023. "Inferring visual space from ultra-fine extra-retinal knowledge of gaze position," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Yujie Wu & Tian Wang & Tingting Zhou & Yang Li & Yi Yang & Weifeng Dai & Yange Zhang & Chuanliang Han & Dajun Xing, 2022. "V1-bypassing suppression leads to direction-specific microsaccade modulation in visual coding and perception," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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