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Loss of lamin A function increases chromatin dynamics in the nuclear interior

Author

Listed:
  • I. Bronshtein

    (Bar Ilan University
    The Mina & Everard Goodman Faculty of Life Sciences and Nanotechnology Institute, Bar Ilan University)

  • E. Kepten

    (Bar Ilan University)

  • I. Kanter

    (Bar Ilan University)

  • S. Berezin

    (Bar Ilan University)

  • M. Lindner

    (Bar Ilan University)

  • Abena B. Redwood

    (School of Medicine, St Louis University)

  • S Mai

    (Manitoba Institute of Cell Biology, University of Manitoba, Cancer Care Manitoba)

  • S. Gonzalo

    (School of Medicine, St Louis University)

  • R. Foisner

    (Max F. Perutz Laboratories, Medical University Vienna, Vienna Biocenter (VBC))

  • Y. Shav-Tal

    (The Mina & Everard Goodman Faculty of Life Sciences and Nanotechnology Institute, Bar Ilan University)

  • Y. Garini

    (Bar Ilan University)

Abstract

Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the principles governing this organization remain unclear. Similarly, it is unknown whether, and how, various proteins regulate chromatin motion and as a result influence nuclear organization. Here by studying the dynamics of different genomic regions in the nucleus of live cells, we show that the genome has highly constrained dynamics. Interestingly, depletion of lamin A strikingly alters genome dynamics, inducing a dramatic transition from slow anomalous diffusion to fast and normal diffusion. In contrast, depletion of LAP2α, a protein that interacts with lamin A and chromatin, has no such effect on genome dynamics. We speculate that chromosomal inter-chain interactions formed by lamin A throughout the nucleus contribute to chromatin dynamics, and suggest that the molecular regulation of chromatin diffusion by lamin A in the nuclear interior is critical for the maintenance of genome organization.

Suggested Citation

  • I. Bronshtein & E. Kepten & I. Kanter & S. Berezin & M. Lindner & Abena B. Redwood & S Mai & S. Gonzalo & R. Foisner & Y. Shav-Tal & Y. Garini, 2015. "Loss of lamin A function increases chromatin dynamics in the nuclear interior," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9044
    DOI: 10.1038/ncomms9044
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    Cited by:

    1. Asaf Ashkenazy-Titelman & Mohammad Khaled Atrash & Alon Boocholez & Noa Kinor & Yaron Shav-Tal, 2022. "RNA export through the nuclear pore complex is directional," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Hirotaka Iijima & Gabrielle Gilmer & Kai Wang & Allison C. Bean & Yuchen He & Hang Lin & Wan-Yee Tang & Daniel Lamont & Chia Tai & Akira Ito & Jeffrey J. Jones & Christopher Evans & Fabrisia Ambrosio, 2023. "Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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