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Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

Author

Listed:
  • Mélanie Chabaud

    (Inserm U932, Institut Curie)

  • Mélina L. Heuzé

    (Inserm U932, Institut Curie)

  • Marine Bretou

    (Inserm U932, Institut Curie)

  • Pablo Vargas

    (Inserm U932, Institut Curie)

  • Paolo Maiuri

    (CNRS UMR144, Institut Curie)

  • Paola Solanes

    (Inserm U932, Institut Curie)

  • Mathieu Maurin

    (Inserm U932, Institut Curie)

  • Emmanuel Terriac

    (CNRS UMR144, Institut Curie)

  • Maël Le Berre

    (CNRS UMR144, Institut Curie)

  • Danielle Lankar

    (Inserm U932, Institut Curie)

  • Tristan Piolot

    (CNRS UMR3215/Inserm U934, Institut Curie)

  • Robert S. Adelstein

    (Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Yingfan Zhang

    (Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health)

  • Michael Sixt

    (Institute of Science and Technology Austria)

  • Jordan Jacobelli

    (National Jewish Health & University of Colorado)

  • Olivier Bénichou

    (CNRS UMR 7600, Université Pierre et Marie Curie)

  • Raphaël Voituriez

    (CNRS UMR 7600, Université Pierre et Marie Curie
    CNRS FRE 3231, Université Pierre et Marie Curie)

  • Matthieu Piel

    (CNRS UMR144, Institut Curie)

  • Ana-Maria Lennon-Duménil

    (Inserm U932, Institut Curie)

Abstract

The immune response relies on the migration of leukocytes and on their ability to stop in precise anatomical locations to fulfil their task. How leukocyte migration and function are coordinated is unknown. Here we show that in immature dendritic cells, which patrol their environment by engulfing extracellular material, cell migration and antigen capture are antagonistic. This antagonism results from transient enrichment of myosin IIA at the cell front, which disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting antigen capture. We further highlight that myosin IIA enrichment at the cell front requires the MHC class II-associated invariant chain (Ii). Thus, by controlling myosin IIA localization, Ii imposes on dendritic cells an intermittent antigen capture behaviour that might facilitate environment patrolling. We propose that the requirement for myosin II in both cell migration and specific cell functions may provide a general mechanism for their coordination in time and space.

Suggested Citation

  • Mélanie Chabaud & Mélina L. Heuzé & Marine Bretou & Pablo Vargas & Paolo Maiuri & Paola Solanes & Mathieu Maurin & Emmanuel Terriac & Maël Le Berre & Danielle Lankar & Tristan Piolot & Robert S. Adels, 2015. "Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells," Nature Communications, Nature, vol. 6(1), pages 1-16, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8526
    DOI: 10.1038/ncomms8526
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    Cited by:

    1. Aravind Chandrasekaran & Kristin Graham & Jeanne C. Stachowiak & Padmini Rangamani, 2024. "Kinetic trapping organizes actin filaments within liquid-like protein droplets," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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