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Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment

Author

Listed:
  • Yael R. Nobel

    (New York University School of Medicine)

  • Laura M. Cox

    (New York University School of Medicine
    New York University School of Medicine)

  • Francis F. Kirigin

    (New York University School of Medicine)

  • Nicholas A. Bokulich

    (New York University School of Medicine)

  • Shingo Yamanishi

    (New York University School of Medicine)

  • Isabel Teitler

    (New York University School of Medicine)

  • Jennifer Chung

    (New York University School of Medicine)

  • Jiho Sohn

    (New York University School of Medicine)

  • Cecily M. Barber

    (New York University School of Medicine)

  • David S. Goldfarb

    (New York University School of Medicine
    New York Harbor Department of Veterans Affairs Medical Center)

  • Kartik Raju

    (New York University School of Medicine)

  • Sahar Abubucker

    (The Genome Institute at Washington University)

  • Yanjiao Zhou

    (The Genome Institute at Washington University
    Washington University School of Medicine
    The Jackson Laboratory for Genomic Medicine)

  • Victoria E. Ruiz

    (New York University School of Medicine)

  • Huilin Li

    (NYU Langone Medical Center)

  • Makedonka Mitreva

    (The Genome Institute at Washington University
    Washington University School of Medicine)

  • Alexander V. Alekseyenko

    (New York University School of Medicine
    Center for Health Informatics and Bioinformatics, New York University School of Medicine)

  • George M. Weinstock

    (The Genome Institute at Washington University
    The Jackson Laboratory for Genomic Medicine)

  • Erica Sodergren

    (The Genome Institute at Washington University
    The Jackson Laboratory for Genomic Medicine)

  • Martin J. Blaser

    (New York University School of Medicine
    New York University School of Medicine
    New York Harbor Department of Veterans Affairs Medical Center)

Abstract

Mammalian species have co-evolved with intestinal microbial communities that can shape development and adapt to environmental changes, including antibiotic perturbation or nutrient flux. In humans, especially children, microbiota disruption is common, yet the dynamic microbiome recovery from early-life antibiotics is still uncharacterized. Here we use a mouse model mimicking paediatric antibiotic use and find that therapeutic-dose pulsed antibiotic treatment (PAT) with a beta-lactam or macrolide alters both host and microbiota development. Early-life PAT accelerates total mass and bone growth, and causes progressive changes in gut microbiome diversity, population structure and metagenomic content, with microbiome effects dependent on the number of courses and class of antibiotic. Whereas control microbiota rapidly adapts to a change in diet, PAT slows the ecological progression, with delays lasting several months with previous macrolide exposure. This study identifies key markers of disturbance and recovery, which may help provide therapeutic targets for microbiota restoration following antibiotic treatment.

Suggested Citation

  • Yael R. Nobel & Laura M. Cox & Francis F. Kirigin & Nicholas A. Bokulich & Shingo Yamanishi & Isabel Teitler & Jennifer Chung & Jiho Sohn & Cecily M. Barber & David S. Goldfarb & Kartik Raju & Sahar A, 2015. "Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment," Nature Communications, Nature, vol. 6(1), pages 1-15, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8486
    DOI: 10.1038/ncomms8486
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    Cited by:

    1. Xu Lin & Hong-Mei Xiao & Hui-Min Liu & Wan-Qiang Lv & Jonathan Greenbaum & Rui Gong & Qiang Zhang & Yuan-Cheng Chen & Cheng Peng & Xue-Juan Xu & Dao-Yan Pan & Zhi Chen & Zhang-Fang Li & Rou Zhou & Xia, 2023. "Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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