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Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Author

Listed:
  • Xu Lin

    (Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
    The Third Affiliated Hospital of Southern Medical University)

  • Hong-Mei Xiao

    (Central South University)

  • Hui-Min Liu

    (Central South University)

  • Wan-Qiang Lv

    (Central South University)

  • Jonathan Greenbaum

    (Tulane University)

  • Rui Gong

    (The Third Affiliated Hospital of Southern Medical University)

  • Qiang Zhang

    (Tulane University)

  • Yuan-Cheng Chen

    (The Third Affiliated Hospital of Southern Medical University)

  • Cheng Peng

    (The Third Affiliated Hospital of Southern Medical University)

  • Xue-Juan Xu

    (The Third Affiliated Hospital of Southern Medical University)

  • Dao-Yan Pan

    (The Third Affiliated Hospital of Southern Medical University)

  • Zhi Chen

    (The Third Affiliated Hospital of Southern Medical University)

  • Zhang-Fang Li

    (The Third Affiliated Hospital of Southern Medical University)

  • Rou Zhou

    (The Third Affiliated Hospital of Southern Medical University)

  • Xia-Fang Wang

    (The Third Affiliated Hospital of Southern Medical University)

  • Jun-Min Lu

    (The Third Affiliated Hospital of Southern Medical University)

  • Zeng-Xin Ao

    (The Third Affiliated Hospital of Southern Medical University)

  • Yu-Qian Song

    (The Third Affiliated Hospital of Southern Medical University)

  • Yin-Hua Zhang

    (The Third Affiliated Hospital of Southern Medical University)

  • Kuan-Jui Su

    (Tulane University)

  • Xiang-He Meng

    (Tulane University)

  • Chang-Li Ge

    (LC-Bio Technologies (Hangzhou) CO., LTD.)

  • Feng-Ye Lv

    (LC-Bio Technologies (Hangzhou) CO., LTD.)

  • Zhe Luo

    (Tulane University)

  • Xing-Ming Shi

    (Augusta University)

  • Qi Zhao

    (University of Tennessee Health Science Center)

  • Bo-Yi Guo

    (University of Alabama at Birmingham)

  • Neng-Jun Yi

    (University of Alabama at Birmingham)

  • Hui Shen

    (Tulane University)

  • Christopher J. Papasian

    (University of Missouri-Kansas City)

  • Jie Shen

    (Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
    The Third Affiliated Hospital of Southern Medical University)

  • Hong-Wen Deng

    (Tulane University)

Abstract

Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing to identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found to be negatively associated with bone mineral density (BMD), which was validated in US white people. Serum valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. VA suppressed RELA protein production (pro-inflammatory), and enhanced IL10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells and enhanced maturation of osteoblasts in vitro. The findings suggest that B. vulgatus and VA may represent promising targets for osteoporosis prevention/treatment.

Suggested Citation

  • Xu Lin & Hong-Mei Xiao & Hui-Min Liu & Wan-Qiang Lv & Jonathan Greenbaum & Rui Gong & Qiang Zhang & Yuan-Cheng Chen & Cheng Peng & Xue-Juan Xu & Dao-Yan Pan & Zhi Chen & Zhang-Fang Li & Rou Zhou & Xia, 2023. "Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42005-y
    DOI: 10.1038/s41467-023-42005-y
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    References listed on IDEAS

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    1. Yael R. Nobel & Laura M. Cox & Francis F. Kirigin & Nicholas A. Bokulich & Shingo Yamanishi & Isabel Teitler & Jennifer Chung & Jiho Sohn & Cecily M. Barber & David S. Goldfarb & Kartik Raju & Sahar A, 2015. "Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment," Nature Communications, Nature, vol. 6(1), pages 1-15, November.
    2. Jiarui Lu & Pixu Shi & Hongzhe Li, 2019. "Generalized linear models with linear constraints for microbiome compositional data," Biometrics, The International Biometric Society, vol. 75(1), pages 235-244, March.
    3. Sébastien Lucas & Yasunori Omata & Jörg Hofmann & Martin Böttcher & Aida Iljazovic & Kerstin Sarter & Olivia Albrecht & Oscar Schulz & Brenda Krishnacoumar & Gerhard Krönke & Martin Herrmann & Dimitri, 2018. "Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
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