IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-42005-y.html
   My bibliography  Save this article

Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Author

Listed:
  • Xu Lin

    (Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
    The Third Affiliated Hospital of Southern Medical University)

  • Hong-Mei Xiao

    (Central South University)

  • Hui-Min Liu

    (Central South University)

  • Wan-Qiang Lv

    (Central South University)

  • Jonathan Greenbaum

    (Tulane University)

  • Rui Gong

    (The Third Affiliated Hospital of Southern Medical University)

  • Qiang Zhang

    (Tulane University)

  • Yuan-Cheng Chen

    (The Third Affiliated Hospital of Southern Medical University)

  • Cheng Peng

    (The Third Affiliated Hospital of Southern Medical University)

  • Xue-Juan Xu

    (The Third Affiliated Hospital of Southern Medical University)

  • Dao-Yan Pan

    (The Third Affiliated Hospital of Southern Medical University)

  • Zhi Chen

    (The Third Affiliated Hospital of Southern Medical University)

  • Zhang-Fang Li

    (The Third Affiliated Hospital of Southern Medical University)

  • Rou Zhou

    (The Third Affiliated Hospital of Southern Medical University)

  • Xia-Fang Wang

    (The Third Affiliated Hospital of Southern Medical University)

  • Jun-Min Lu

    (The Third Affiliated Hospital of Southern Medical University)

  • Zeng-Xin Ao

    (The Third Affiliated Hospital of Southern Medical University)

  • Yu-Qian Song

    (The Third Affiliated Hospital of Southern Medical University)

  • Yin-Hua Zhang

    (The Third Affiliated Hospital of Southern Medical University)

  • Kuan-Jui Su

    (Tulane University)

  • Xiang-He Meng

    (Tulane University)

  • Chang-Li Ge

    (LC-Bio Technologies (Hangzhou) CO., LTD.)

  • Feng-Ye Lv

    (LC-Bio Technologies (Hangzhou) CO., LTD.)

  • Zhe Luo

    (Tulane University)

  • Xing-Ming Shi

    (Augusta University)

  • Qi Zhao

    (University of Tennessee Health Science Center)

  • Bo-Yi Guo

    (University of Alabama at Birmingham)

  • Neng-Jun Yi

    (University of Alabama at Birmingham)

  • Hui Shen

    (Tulane University)

  • Christopher J. Papasian

    (University of Missouri-Kansas City)

  • Jie Shen

    (Shunde Hospital of Southern Medical University (The First People’s Hospital of Shunde)
    The Third Affiliated Hospital of Southern Medical University)

  • Hong-Wen Deng

    (Tulane University)

Abstract

Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese cohort of peri-/post-menopausal women with metagenomics/targeted metabolomics/whole-genome sequencing to identify novel microbiome-related biomarkers for bone health. Bacteroides vulgatus was found to be negatively associated with bone mineral density (BMD), which was validated in US white people. Serum valeric acid (VA), a microbiota derived metabolite, was positively associated with BMD and causally downregulated by B. vulgatus. Ovariectomized mice fed B. vulgatus demonstrated increased bone resorption and poorer bone micro-structure, while those fed VA demonstrated reduced bone resorption and better bone micro-structure. VA suppressed RELA protein production (pro-inflammatory), and enhanced IL10 mRNA expression (anti-inflammatory), leading to suppressed maturation of osteoclast-like cells and enhanced maturation of osteoblasts in vitro. The findings suggest that B. vulgatus and VA may represent promising targets for osteoporosis prevention/treatment.

Suggested Citation

  • Xu Lin & Hong-Mei Xiao & Hui-Min Liu & Wan-Qiang Lv & Jonathan Greenbaum & Rui Gong & Qiang Zhang & Yuan-Cheng Chen & Cheng Peng & Xue-Juan Xu & Dao-Yan Pan & Zhi Chen & Zhang-Fang Li & Rou Zhou & Xia, 2023. "Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42005-y
    DOI: 10.1038/s41467-023-42005-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-42005-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-42005-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yael R. Nobel & Laura M. Cox & Francis F. Kirigin & Nicholas A. Bokulich & Shingo Yamanishi & Isabel Teitler & Jennifer Chung & Jiho Sohn & Cecily M. Barber & David S. Goldfarb & Kartik Raju & Sahar A, 2015. "Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment," Nature Communications, Nature, vol. 6(1), pages 1-15, November.
    2. Jiarui Lu & Pixu Shi & Hongzhe Li, 2019. "Generalized linear models with linear constraints for microbiome compositional data," Biometrics, The International Biometric Society, vol. 75(1), pages 235-244, March.
    3. Sébastien Lucas & Yasunori Omata & Jörg Hofmann & Martin Böttcher & Aida Iljazovic & Kerstin Sarter & Olivia Albrecht & Oscar Schulz & Brenda Krishnacoumar & Gerhard Krönke & Martin Herrmann & Dimitri, 2018. "Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lingjing Jiang & Niina Haiminen & Anna‐Paola Carrieri & Shi Huang & Yoshiki Vázquez‐Baeza & Laxmi Parida & Ho‐Cheol Kim & Austin D. Swafford & Rob Knight & Loki Natarajan, 2022. "Utilizing stability criteria in choosing feature selection methods yields reproducible results in microbiome data," Biometrics, The International Biometric Society, vol. 78(3), pages 1155-1167, September.
    2. Jordi Saperas-Riera & Glòria Mateu-Figueras & Josep Antoni Martín-Fernández, 2024. "L p -Norm for Compositional Data: Exploring the CoDa L 1 -Norm in Penalised Regression," Mathematics, MDPI, vol. 12(9), pages 1-16, May.
    3. Sean M Devlin & Axel Martin & Irina Ostrovnaya, 2021. "Identifying prognostic pairwise relationships among bacterial species in microbiome studies," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-12, November.
    4. G. S. Monti & P. Filzmoser, 2022. "Robust logistic zero-sum regression for microbiome compositional data," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 16(2), pages 301-324, June.
    5. Arun Srinivasan & Lingzhou Xue & Xiang Zhan, 2021. "Compositional knockoff filter for high‐dimensional regression analysis of microbiome data," Biometrics, The International Biometric Society, vol. 77(3), pages 984-995, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42005-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.