IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8364.html
   My bibliography  Save this article

Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells

Author

Listed:
  • Qionger He

    (Physiology and Pharmacology, UCL
    Present address: Department of Physiology, Northwestern University, 303 E Chicago Avenue, Ward Building, Suite 5-223, Chicago, IL 60601, USA)

  • Ian Duguid

    (Physiology and Pharmacology, UCL
    Present address: Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, Scotland EH8 9XD, UK)

  • Beverley Clark

    (Wolfson Institute for Biomedical Research, UCL)

  • Patrizia Panzanelli

    (University of Turin)

  • Bijal Patel

    (Physiology and Pharmacology, UCL)

  • Philip Thomas

    (Physiology and Pharmacology, UCL)

  • Jean-Marc Fritschy

    (Institute of Pharmacology, University of Zurich)

  • Trevor G. Smart

    (Physiology and Pharmacology, UCL)

Abstract

Inhibitory synaptic plasticity is important for shaping both neuronal excitability and network activity. Here we investigate the input and GABAA receptor subunit specificity of inhibitory synaptic plasticity by studying cerebellar interneuron–Purkinje cell (PC) synapses. Depolarizing PCs initiated a long-lasting increase in GABA-mediated synaptic currents. By stimulating individual interneurons, this plasticity was observed at somatodendritic basket cell synapses, but not at distal dendritic stellate cell synapses. Basket cell synapses predominantly express β2-subunit-containing GABAA receptors; deletion of the β2-subunit ablates this plasticity, demonstrating its reliance on GABAA receptor subunit composition. The increase in synaptic currents is dependent upon an increase in newly synthesized cell surface synaptic GABAA receptors and is abolished by preventing CaMKII phosphorylation of GABAA receptors. Our results reveal a novel GABAA receptor subunit- and input-specific form of inhibitory synaptic plasticity that regulates the temporal firing pattern of the principal output cells of the cerebellum.

Suggested Citation

  • Qionger He & Ian Duguid & Beverley Clark & Patrizia Panzanelli & Bijal Patel & Philip Thomas & Jean-Marc Fritschy & Trevor G. Smart, 2015. "Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8364
    DOI: 10.1038/ncomms8364
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms8364
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms8364?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Hao & Haowen Liu & Xian-Ting Zeng & Ya Wang & Wan-Xin Zeng & Kang-Ying Qian & Lei Li & Ming-Xuan Chi & Shangbang Gao & Zhitao Hu & Xia-Jing Tong, 2023. "UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8364. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.